PDUFAoutcome: unknownconf 0.99

aficamten — PDUFA

$CYTK · CYTOKINETICS INC · obstructive hypertrophic cardiomyopathy (oHCM)

Event date

December 26, 2025

162 days ago

Sponsor runway

3 mo

$129.8M liquid

Evidence

“The Prescription Drug User Fee Act ("PDUFA") target action date for the NDA for aficamten remains December 26, 2025.”

Source: 8-K filed 2025-09-16View on EDGAR ↗0001193125-25-204991

Comparable historical pdufas· last 5 years · same event type

60% hit rate (3/5)

Ticker	Drug	Date	Outcome
$RCKT	kresladi	2026-03-28	success
$RYTM	imcivree	2026-03-20	success
$ALDX	reproxalap	2025-12-16	unknown
$BCRX	orladeyo	2025-12-12	success
$OMER	narsoplimab	2025-09-25	unknown
$BCRX	orladeyo (berotralstat)	2025-09-12	unknown
$ETON	et-400	2025-05-28	unknown
$ALDX	reproxalap	2025-04-02	failure
$IONS	olezarsen	2024-12-19	unknown
$RCKT	kresladi	2024-06-30	failure

Recent insider activity· ±90 days

12 insiders · 0 buys · 42 sells

Sell10b5-1

2026-03-18

Callos Andrew

EVP, Chief Commercial Officer

1,930 @ $62.07$120K

Sell

2026-03-17

Callos Andrew

EVP, Chief Commercial Officer

2,916 @ $62.15$181K

Sell

2026-03-17

Malik Fady Ibraham

EVP Research & Development

7,636 @ $62.15$475K

Sell

2026-03-17

Malik Fady Ibraham

EVP Research & Development

4,397 @ $62.15$273K

Sell

2026-03-17

Callos Andrew

EVP, Chief Commercial Officer

5,626 @ $62.15$350K

Sell

2026-03-17

Blum Robert I

President & CEO

12,673 @ $62.15$788K

Sell

2026-03-17

Blum Robert I

President & CEO

23,928 @ $62.15$1.49M

Sell

2026-03-17

Lee Sung

EVP, Chief Financial Officer

4,935 @ $62.15$307K

Sell10b5-1

2026-03-16

Callos Andrew

EVP, Chief Commercial Officer

1,709 @ $61.03$104K

Grant

2026-03-15

Blum Robert I

President & CEO

1,665 @ ——

Grant

2026-03-15

Blum Robert I

President & CEO

111,864 @ ——

Grant

2026-03-15

Callos Andrew

EVP, Chief Commercial Officer

20,646 @ ——

Grant

2026-03-15

Callos Andrew

EVP, Chief Commercial Officer

13,320 @ ——

Grant

2026-03-15

Callos Andrew

EVP, Chief Commercial Officer

1,665 @ ——

Grant

2026-03-15

Callos Andrew

EVP, Chief Commercial Officer

29,480 @ ——

Grant

2026-03-15

Hessekiel Jeffrey

Chief Legal & Admin Officer

20,646 @ ——

Grant

2026-03-15

Hessekiel Jeffrey

Chief Legal & Admin Officer

8,325 @ ——

Grant

2026-03-15

Hessekiel Jeffrey

Chief Legal & Admin Officer

22,820 @ ——

Grant

2026-03-15

Lee Sung

EVP, Chief Financial Officer

20,646 @ ——

Grant

2026-03-15

Lee Sung

EVP, Chief Financial Officer

1,665 @ ——

Grant

2026-03-15

Lee Sung

EVP, Chief Financial Officer

29,480 @ ——

Grant

2026-03-15

Malik Fady Ibraham

EVP Research & Development

27,306 @ ——

Grant

2026-03-15

Malik Fady Ibraham

EVP Research & Development

1,665 @ ——

Grant

2026-03-15

Malik Fady Ibraham

EVP Research & Development

39,527 @ ——

Grant

2026-03-15

Blum Robert I

President & CEO

75,258 @ ——

Sell

2026-03-09

Callos Andrew

EVP, Chief Commercial Officer

2,582 @ $60.72$157K

Sell

2026-03-09

Malik Fady Ibraham

EVP Research & Development

2,907 @ $60.72$177K

Sell

2026-03-09

Blum Robert I

President & CEO

7,931 @ $60.72$482K

Exercise10b5-1

2026-03-05

Callos Andrew

EVP, Chief Commercial Officer

11,000 @ $39.13$430K

Sell10b5-1

2026-03-05

Callos Andrew

EVP, Chief Commercial Officer

15,000 @ $61.87$928K

Sell10b5-1

2026-03-05

Callos Andrew

EVP, Chief Commercial Officer

11,000 @ $61.88$681K

Exercise10b5-1

2026-03-05

Callos Andrew

EVP, Chief Commercial Officer

15,000 @ $23.26$349K

Sell10b5-1

2026-03-02

PARSHALL B LYNNE

Director

5,000 @ $61.21$306K

Exercise10b5-1

2026-03-02

Callos Andrew

EVP, Chief Commercial Officer

886 @ $37.63$33K

Sell10b5-1

2026-03-02

Callos Andrew

EVP, Chief Commercial Officer

886 @ $61.62$55K

Exercise10b5-1

2026-02-05

Callos Andrew

EVP, Chief Commercial Officer

15,000 @ $23.26$349K

Sell10b5-1

2026-02-05

Callos Andrew

EVP, Chief Commercial Officer

15,000 @ $61.93$929K

Exercise10b5-1

2026-02-02

Callos Andrew

EVP, Chief Commercial Officer

886 @ $37.63$33K

Sell10b5-1

2026-02-02

Callos Andrew

EVP, Chief Commercial Officer

886 @ $62.10$55K

Grant

2026-01-15

Daly James M

Director

197 @ $63.44$12K

Grant

2026-01-15

Wysenski Nancy

Director

98 @ $63.44$6K

Grant

2026-01-15

WIERENGA WENDELL

Director

98 @ $63.44$6K

Grant

2026-01-15

Kaye Edward M. MD

Director

197 @ $63.44$12K

Grant

2026-01-15

HENDERSON JOHN T

Director

334 @ $63.44$21K

Grant

2026-01-15

Harrington Robert Arthur

Director

197 @ $63.44$12K

Exercise10b5-1

2026-01-05

Callos Andrew

EVP, Chief Commercial Officer

15,000 @ $23.26$349K

Sell10b5-1

2026-01-05

Callos Andrew

EVP, Chief Commercial Officer

15,000 @ $60.28$904K

Sell10b5-1

2026-01-02

Callos Andrew

EVP, Chief Commercial Officer

913 @ $62.09$57K

Exercise10b5-1

2026-01-02

Callos Andrew

EVP, Chief Commercial Officer

885 @ $37.63$33K

Sell10b5-1

2026-01-02

Callos Andrew

EVP, Chief Commercial Officer

885 @ $63.16$56K

+ 61 more

Date	Insider	Action	Shares	Price	Value
2026-03-18	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	1,930	$62.07	$120K
2026-03-17	Callos AndrewEVP, Chief Commercial Officer	Sell	2,916	$62.15	$181K
2026-03-17	Malik Fady IbrahamEVP Research & Development	Sell	7,636	$62.15	$475K
2026-03-17	Malik Fady IbrahamEVP Research & Development	Sell	4,397	$62.15	$273K
2026-03-17	Callos AndrewEVP, Chief Commercial Officer	Sell	5,626	$62.15	$350K
2026-03-17	Blum Robert IPresident & CEO	Sell	12,673	$62.15	$788K
2026-03-17	Blum Robert IPresident & CEO	Sell	23,928	$62.15	$1.49M
2026-03-17	Lee SungEVP, Chief Financial Officer	Sell	4,935	$62.15	$307K
2026-03-16	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	1,709	$61.03	$104K
2026-03-15	Blum Robert IPresident & CEO	Grant	1,665	—	—
2026-03-15	Blum Robert IPresident & CEO	Grant	111,864	—	—
2026-03-15	Callos AndrewEVP, Chief Commercial Officer	Grant	20,646	—	—
2026-03-15	Callos AndrewEVP, Chief Commercial Officer	Grant	13,320	—	—
2026-03-15	Callos AndrewEVP, Chief Commercial Officer	Grant	1,665	—	—
2026-03-15	Callos AndrewEVP, Chief Commercial Officer	Grant	29,480	—	—
2026-03-15	Hessekiel JeffreyChief Legal & Admin Officer	Grant	20,646	—	—
2026-03-15	Hessekiel JeffreyChief Legal & Admin Officer	Grant	8,325	—	—
2026-03-15	Hessekiel JeffreyChief Legal & Admin Officer	Grant	22,820	—	—
2026-03-15	Lee SungEVP, Chief Financial Officer	Grant	20,646	—	—
2026-03-15	Lee SungEVP, Chief Financial Officer	Grant	1,665	—	—
2026-03-15	Lee SungEVP, Chief Financial Officer	Grant	29,480	—	—
2026-03-15	Malik Fady IbrahamEVP Research & Development	Grant	27,306	—	—
2026-03-15	Malik Fady IbrahamEVP Research & Development	Grant	1,665	—	—
2026-03-15	Malik Fady IbrahamEVP Research & Development	Grant	39,527	—	—
2026-03-15	Blum Robert IPresident & CEO	Grant	75,258	—	—
2026-03-09	Callos AndrewEVP, Chief Commercial Officer	Sell	2,582	$60.72	$157K
2026-03-09	Malik Fady IbrahamEVP Research & Development	Sell	2,907	$60.72	$177K
2026-03-09	Blum Robert IPresident & CEO	Sell	7,931	$60.72	$482K
2026-03-05	Callos AndrewEVP, Chief Commercial Officer	Exercise10b5-1	11,000	$39.13	$430K
2026-03-05	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	15,000	$61.87	$928K
2026-03-05	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	11,000	$61.88	$681K
2026-03-05	Callos AndrewEVP, Chief Commercial Officer	Exercise10b5-1	15,000	$23.26	$349K
2026-03-02	PARSHALL B LYNNEDirector	Sell10b5-1	5,000	$61.21	$306K
2026-03-02	Callos AndrewEVP, Chief Commercial Officer	Exercise10b5-1	886	$37.63	$33K
2026-03-02	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	886	$61.62	$55K
2026-02-05	Callos AndrewEVP, Chief Commercial Officer	Exercise10b5-1	15,000	$23.26	$349K
2026-02-05	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	15,000	$61.93	$929K
2026-02-02	Callos AndrewEVP, Chief Commercial Officer	Exercise10b5-1	886	$37.63	$33K
2026-02-02	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	886	$62.10	$55K
2026-01-15	Daly James MDirector	Grant	197	$63.44	$12K
2026-01-15	Wysenski NancyDirector	Grant	98	$63.44	$6K
2026-01-15	WIERENGA WENDELLDirector	Grant	98	$63.44	$6K
2026-01-15	Kaye Edward M. MDDirector	Grant	197	$63.44	$12K
2026-01-15	HENDERSON JOHN TDirector	Grant	334	$63.44	$21K
2026-01-15	Harrington Robert ArthurDirector	Grant	197	$63.44	$12K
2026-01-05	Callos AndrewEVP, Chief Commercial Officer	Exercise10b5-1	15,000	$23.26	$349K
2026-01-05	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	15,000	$60.28	$904K
2026-01-02	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	913	$62.09	$57K
2026-01-02	Callos AndrewEVP, Chief Commercial Officer	Exercise10b5-1	885	$37.63	$33K
2026-01-02	Callos AndrewEVP, Chief Commercial Officer	Sell10b5-1	885	$63.16	$56K

+ 61 more transactions

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