Yeji
CRLconf 0.98

patisiran — CRL

$ALNY · ALNYLAM PHARMACEUTICALS, INC. · cardiomyopathy of transthyretin-mediated (ATTR) amyloidosis
Event date
October 9, 2023
971 days ago
Sponsor runway
cash-flow +
$1.66B liquid

Evidence

“On October 9, 2023, Alnylam Pharmaceuticals, Inc. issued a press release...announcing receipt of a Complete Response Letter from the United States Food and Drug Administration in regard to the Company's supplemental new drug application for patisiran, an investigational RNAi therapeutic for the treatment of the cardiomyopathy of transthyretin-mediated (ATTR) amyloidosis.”
Source: 8-K filed 2023-10-10View on EDGAR ↗0001193125-23-253084

Comparable historical crls· last 5 years · same event type

No comparable historical outcomes in our database yet — backfill of past readouts arrives next ingestion cycle.

Recent insider activity· ±90 days

5 insiders · 0 buys · 35 sells
Sell10b5-1
2023-12-27
BONNEY MICHAEL W
Director
30,000 @ $195.00$5.85M
Exercise10b5-1
2023-12-27
BONNEY MICHAEL W
Director
30,000 @ $96.45$2.89M
Sell
2023-08-07
Garg Pushkal
EVP Chief R&D
240 @ $185.32$44K
Sell
2023-08-07
Garg Pushkal
EVP Chief R&D
3,112 @ $183.58$571K
Sell
2023-08-07
Garg Pushkal
EVP Chief R&D
814 @ $184.65$150K
Sell
2023-08-04
Garg Pushkal
EVP Chief R&D
15 @ $188.40$3K
Sell
2023-08-04
Garg Pushkal
EVP Chief R&D
164 @ $189.31$31K
Sell
2023-08-04
Poulton Jeffrey V.
EVP, Chief Financial Officer
944 @ $186.39$176K
Sell
2023-08-04
Garg Pushkal
EVP Chief R&D
658 @ $184.70$122K
Sell
2023-08-04
Garg Pushkal
EVP Chief R&D
1,593 @ $185.54$296K
Sell
2023-08-04
Garg Pushkal
EVP Chief R&D
945 @ $186.39$176K
Sell
2023-08-04
Garg Pushkal
EVP Chief R&D
86 @ $187.37$16K
Sell
2023-08-04
Poulton Jeffrey V.
EVP, Chief Financial Officer
1,593 @ $185.54$296K
Sell
2023-08-04
Poulton Jeffrey V.
EVP, Chief Financial Officer
86 @ $187.37$16K
Sell
2023-08-04
Poulton Jeffrey V.
EVP, Chief Financial Officer
15 @ $188.40$3K
Sell
2023-08-04
Poulton Jeffrey V.
EVP, Chief Financial Officer
164 @ $189.31$31K
Sell
2023-08-04
Greenstreet Yvonne
Chief Executive Officer
771 @ $184.70$142K
Sell
2023-08-04
Greenstreet Yvonne
Chief Executive Officer
1,869 @ $185.54$347K
Sell
2023-08-04
Greenstreet Yvonne
Chief Executive Officer
1,107 @ $186.39$206K
Sell
2023-08-04
Greenstreet Yvonne
Chief Executive Officer
101 @ $187.37$19K
Sell
2023-08-04
Greenstreet Yvonne
Chief Executive Officer
17 @ $188.40$3K
Sell
2023-08-04
Greenstreet Yvonne
Chief Executive Officer
192 @ $189.31$36K
Sell
2023-08-04
Vaishnaw Akshay
President
771 @ $184.70$142K
Sell
2023-08-04
Vaishnaw Akshay
President
1,869 @ $185.54$347K
Sell
2023-08-04
Vaishnaw Akshay
President
1,107 @ $186.39$206K
Sell
2023-08-04
Vaishnaw Akshay
President
101 @ $187.37$19K
Sell
2023-08-04
Vaishnaw Akshay
President
17 @ $188.40$3K
Sell
2023-08-04
Vaishnaw Akshay
President
192 @ $189.31$36K
Sell
2023-08-04
Poulton Jeffrey V.
EVP, Chief Financial Officer
658 @ $184.70$122K
Grant
2023-08-03
Garg Pushkal
EVP Chief R&D
3,109 @ ——
Grant
2023-08-03
Poulton Jeffrey V.
EVP, Chief Financial Officer
4,518 @ ——
Grant
2023-08-03
Poulton Jeffrey V.
EVP, Chief Financial Officer
3,109 @ ——
Sell
2023-08-03
BONNEY MICHAEL W
Director
300 @ $181.08$54K
Grant
2023-08-03
Vaishnaw Akshay
President
5,082 @ ——
Grant
2023-08-03
Garg Pushkal
EVP Chief R&D
4,518 @ ——
Grant
2023-08-03
Vaishnaw Akshay
President
3,859 @ ——
Sell
2023-08-03
BONNEY MICHAEL W
Director
500 @ $182.45$91K
Sell
2023-08-03
BONNEY MICHAEL W
Director
560 @ $183.75$103K
Grant
2023-08-03
Greenstreet Yvonne
Chief Executive Officer
5,082 @ ——
Grant
2023-08-03
Greenstreet Yvonne
Chief Executive Officer
3,859 @ ——
Sell
2023-08-03
BONNEY MICHAEL W
Director
1,535 @ $184.89$284K
Sell
2023-08-03
BONNEY MICHAEL W
Director
1,714 @ $185.99$319K
Sell
2023-08-03
BONNEY MICHAEL W
Director
1,389 @ $187.04$260K
Sell
2023-08-03
BONNEY MICHAEL W
Director
450 @ $187.71$84K
Exercise
2023-08-02
BONNEY MICHAEL W
Director
22,477 @ ——
← All catalysts for $ALNY