PDUFAconf 0.99

exagamglogene autotemcel — PDUFA

$CRSP · CRISPR Therapeutics AG · severe sickle cell disease (SCD)

Event date

March 30, 2024

798 days ago

Sponsor runway

6+ yrs

$2.44B liquid

Evidence

“PDUFA target action date of December 8, 2023, for SCD and March 30, 2024, for TDT”

Source: Press release · 2023-06-09View press release ↗

Comparable historical pdufas· last 5 years · same indication

Ticker	Drug	Date	Outcome
$CRSP	exagamglogene autotemcel	2023-12-08	unknown

Recent insider activity· ±90 days

14 insiders · 0 buys · 18 sells

Sell

2024-06-21

Bruno Julianne

Chief Operating Officer

3,366 @ $56.09$189K

Exercise

2024-06-20

Bruno Julianne

Chief Operating Officer

7,000 @ ——

Grant

2024-05-30

Behbahani Ali

Director

13,000 @ ——

Grant

2024-05-30

Mahatme Sandesh

Director

13,000 @ ——

Grant

2024-05-30

Fardis Maria

Director

13,000 @ ——

Grant

2024-05-30

Greene John

Director

13,000 @ ——

Grant

2024-05-30

Rommel Christian

Director

26,000 @ ——

Grant

2024-05-30

High Katherine A

Director

13,000 @ ——

Grant

2024-05-30

Treco Douglas A

Director

13,000 @ ——

Grant

2024-05-30

Fleming Harold Edward

Director

13,000 @ ——

Grant

2024-05-30

George Simeon

Director

13,000 @ ——

Grant

2024-05-28

Patel Naimish

Chief Medical Officer

85,000 @ ——

Grant

2024-05-28

Patel Naimish

Chief Medical Officer

40,000 @ ——

Grant

2024-05-23

Bruno Julianne

Chief Operating Officer

20,000 @ ——

Exercise10b5-1

2024-04-15

Kulkarni Samarth

Chief Executive Officer

19,582 @ $19.12$374K

Sell10b5-1

2024-04-15

Kulkarni Samarth

Chief Executive Officer

18,378 @ $59.88$1.10M

Sell10b5-1

2024-04-15

Kulkarni Samarth

Chief Executive Officer

1,204 @ $60.40$73K

Grant

2024-03-20

KASINGER JAMES R.

General Counsel and Secretary

33,333 @ ——

Grant

2024-03-20

KASINGER JAMES R.

General Counsel and Secretary

25,000 @ ——

Grant

2024-03-20

Prasad Raju

Chief Financial Officer

36,168 @ ——

Grant

2024-03-20

Prasad Raju

Chief Financial Officer

25,000 @ ——

Grant

2024-03-20

Kulkarni Samarth

Chief Executive Officer

105,000 @ ——

Grant

2024-03-20

Kulkarni Samarth

Chief Executive Officer

78,750 @ ——

Sell10b5-1

2024-03-15

Kulkarni Samarth

Chief Executive Officer

10,613 @ $71.97$764K

Sell

2024-03-15

Prasad Raju

Chief Financial Officer

3,524 @ $72.69$256K

Exercise10b5-1

2024-03-15

Kulkarni Samarth

Chief Executive Officer

20,000 @ $19.12$382K

Sell10b5-1

2024-03-15

Kulkarni Samarth

Chief Executive Officer

9,387 @ $73.06$686K

Exercise

2024-03-14

Prasad Raju

Chief Financial Officer

10,000 @ ——

Sell

2024-03-12

KASINGER JAMES R.

General Counsel and Secretary

1,146 @ $74.44$85K

Sell

2024-03-12

Kulkarni Samarth

Chief Executive Officer

4,583 @ $74.44$341K

Sell

2024-03-11

Kulkarni Samarth

Chief Executive Officer

9,802 @ $78.26$767K

Exercise

2024-03-11

KASINGER JAMES R.

General Counsel and Secretary

2,250 @ ——

Sell

2024-03-11

KASINGER JAMES R.

General Counsel and Secretary

2,801 @ $78.26$219K

Exercise

2024-03-11

Kulkarni Samarth

Chief Executive Officer

9,000 @ ——

Exercise

2024-03-10

KASINGER JAMES R.

General Counsel and Secretary

5,500 @ ——

Exercise

2024-03-10

Kulkarni Samarth

Chief Executive Officer

19,250 @ ——

Grant

2024-02-27

George Simeon

Director

63,177 @ $71.50$4.52M

Grant

2024-02-27

George Simeon

Director

216,578 @ $71.50$15.49M

Grant

2024-02-27

George Simeon

Director

769,196 @ $71.50$55.00M

Sell

2024-02-20

Kulkarni Samarth

Chief Executive Officer

6,370 @ $79.67$507K

Sell

2024-02-20

KASINGER JAMES R.

General Counsel and Secretary

1,913 @ $79.67$152K

Exercise

2024-02-18

KASINGER JAMES R.

General Counsel and Secretary

3,825 @ ——

Exercise

2024-02-18

Kulkarni Samarth

Chief Executive Officer

13,250 @ ——

Exercise10b5-1

2024-02-15

Kulkarni Samarth

Chief Executive Officer

20,000 @ $19.12$382K

Sell10b5-1

2024-02-15

Kulkarni Samarth

Chief Executive Officer

12,949 @ $79.94$1.04M

Sell10b5-1

2024-02-15

Kulkarni Samarth

Chief Executive Officer

5,951 @ $81.04$482K

Sell10b5-1

2024-02-15

Kulkarni Samarth

Chief Executive Officer

1,100 @ $81.66$90K

Exercise10b5-1

2024-01-29

Kulkarni Samarth

Chief Executive Officer

50,000 @ $19.12$956K

Sell10b5-1

2024-01-29

Kulkarni Samarth

Chief Executive Officer

49,300 @ $60.50$2.98M

Sell10b5-1

2024-01-29

Kulkarni Samarth

Chief Executive Officer

700 @ $61.10$43K

+ 2 more

Date	Insider	Action	Shares	Price	Value
2024-06-21	Bruno JulianneChief Operating Officer	Sell	3,366	$56.09	$189K
2024-06-20	Bruno JulianneChief Operating Officer	Exercise	7,000	—	—
2024-05-30	Behbahani AliDirector	Grant	13,000	—	—
2024-05-30	Mahatme SandeshDirector	Grant	13,000	—	—
2024-05-30	Fardis MariaDirector	Grant	13,000	—	—
2024-05-30	Greene JohnDirector	Grant	13,000	—	—
2024-05-30	Rommel ChristianDirector	Grant	26,000	—	—
2024-05-30	High Katherine ADirector	Grant	13,000	—	—
2024-05-30	Treco Douglas ADirector	Grant	13,000	—	—
2024-05-30	Fleming Harold EdwardDirector	Grant	13,000	—	—
2024-05-30	George SimeonDirector	Grant	13,000	—	—
2024-05-28	Patel NaimishChief Medical Officer	Grant	85,000	—	—
2024-05-28	Patel NaimishChief Medical Officer	Grant	40,000	—	—
2024-05-23	Bruno JulianneChief Operating Officer	Grant	20,000	—	—
2024-04-15	Kulkarni SamarthChief Executive Officer	Exercise10b5-1	19,582	$19.12	$374K
2024-04-15	Kulkarni SamarthChief Executive Officer	Sell10b5-1	18,378	$59.88	$1.10M
2024-04-15	Kulkarni SamarthChief Executive Officer	Sell10b5-1	1,204	$60.40	$73K
2024-03-20	KASINGER JAMES R.General Counsel and Secretary	Grant	33,333	—	—
2024-03-20	KASINGER JAMES R.General Counsel and Secretary	Grant	25,000	—	—
2024-03-20	Prasad RajuChief Financial Officer	Grant	36,168	—	—
2024-03-20	Prasad RajuChief Financial Officer	Grant	25,000	—	—
2024-03-20	Kulkarni SamarthChief Executive Officer	Grant	105,000	—	—
2024-03-20	Kulkarni SamarthChief Executive Officer	Grant	78,750	—	—
2024-03-15	Kulkarni SamarthChief Executive Officer	Sell10b5-1	10,613	$71.97	$764K
2024-03-15	Prasad RajuChief Financial Officer	Sell	3,524	$72.69	$256K
2024-03-15	Kulkarni SamarthChief Executive Officer	Exercise10b5-1	20,000	$19.12	$382K
2024-03-15	Kulkarni SamarthChief Executive Officer	Sell10b5-1	9,387	$73.06	$686K
2024-03-14	Prasad RajuChief Financial Officer	Exercise	10,000	—	—
2024-03-12	KASINGER JAMES R.General Counsel and Secretary	Sell	1,146	$74.44	$85K
2024-03-12	Kulkarni SamarthChief Executive Officer	Sell	4,583	$74.44	$341K
2024-03-11	Kulkarni SamarthChief Executive Officer	Sell	9,802	$78.26	$767K
2024-03-11	KASINGER JAMES R.General Counsel and Secretary	Exercise	2,250	—	—
2024-03-11	KASINGER JAMES R.General Counsel and Secretary	Sell	2,801	$78.26	$219K
2024-03-11	Kulkarni SamarthChief Executive Officer	Exercise	9,000	—	—
2024-03-10	KASINGER JAMES R.General Counsel and Secretary	Exercise	5,500	—	—
2024-03-10	Kulkarni SamarthChief Executive Officer	Exercise	19,250	—	—
2024-02-27	George SimeonDirector	Grant	63,177	$71.50	$4.52M
2024-02-27	George SimeonDirector	Grant	216,578	$71.50	$15.49M
2024-02-27	George SimeonDirector	Grant	769,196	$71.50	$55.00M
2024-02-20	Kulkarni SamarthChief Executive Officer	Sell	6,370	$79.67	$507K
2024-02-20	KASINGER JAMES R.General Counsel and Secretary	Sell	1,913	$79.67	$152K
2024-02-18	KASINGER JAMES R.General Counsel and Secretary	Exercise	3,825	—	—
2024-02-18	Kulkarni SamarthChief Executive Officer	Exercise	13,250	—	—
2024-02-15	Kulkarni SamarthChief Executive Officer	Exercise10b5-1	20,000	$19.12	$382K
2024-02-15	Kulkarni SamarthChief Executive Officer	Sell10b5-1	12,949	$79.94	$1.04M
2024-02-15	Kulkarni SamarthChief Executive Officer	Sell10b5-1	5,951	$81.04	$482K
2024-02-15	Kulkarni SamarthChief Executive Officer	Sell10b5-1	1,100	$81.66	$90K
2024-01-29	Kulkarni SamarthChief Executive Officer	Exercise10b5-1	50,000	$19.12	$956K
2024-01-29	Kulkarni SamarthChief Executive Officer	Sell10b5-1	49,300	$60.50	$2.98M
2024-01-29	Kulkarni SamarthChief Executive Officer	Sell10b5-1	700	$61.10	$43K

+ 2 more transactions

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