NDA/BLA filedoutcome: unknownconf 0.85

NDA/BLA filed

$AXSM · Axsome Therapeutics, Inc.

Event date

December 31, 2025

157 days ago

Sponsor runway

44 mo

$305.1M liquid

Evidence

“On December 31, 2025, Axsome Therapeutics, Inc. (the ”

Source: 8-K filed 2025-12-31View on EDGAR ↗0001193125-25-337644

Comparable historical nda/bla fileds· last 5 years · same event type

Ticker	Drug	Date	Outcome
$RCKT	kresladi	2025-10-14	unknown
$ALDX	reproxalap	2025-07-17	unknown
$ETON	et-600	2025-07-08	unknown
$BCRX	orladeyo (berotralstat)	2025-05-14	unknown
$CORT	relacorilant	2025-03-03	unknown
$ALDX	reproxalap	2024-11-01	unknown
$AXSM	axs-07	2024-09-04	unknown
$RCKT	kresladi	2023-10-02	unknown
$GERN	imetelstat	2023-08-21	unknown
$CRMD	defencath	2023-06-21	unknown

Recent insider activity· ±90 days

7 insiders · 0 buys · 19 sells

Sell10b5-1

2026-02-26

Jacobson Mark L.

Chief Operating Officer

35,378 @ $161.88$5.73M

Grant

2026-02-26

Jacobson Mark L.

Chief Operating Officer

19,663 @ ——

Grant

2026-02-26

Pizzie Nick

Chief Financial Officer

18,570 @ ——

Grant

2026-02-26

Murdock Hunter R.

General Counsel

16,385 @ ——

Exercise10b5-1

2026-02-26

Jacobson Mark L.

Chief Operating Officer

35,378 @ $2.85$101K

Grant

2026-02-26

TABUTEAU HERRIOT

Chief Executive Officer

54,623 @ ——

Grant

2026-02-26

Maizel Ari

Chief Commercial Officer

16,385 @ ——

Sell10b5-1

2026-02-26

Coleman Mark

Director

25,000 @ $161.11$4.03M

Exercise

2026-02-23

Coleman Mark

Director

6,250 @ $4.95$31K

Exercise

2026-02-20

Coleman Mark

Director

12,485 @ $4.95$62K

Exercise

2026-02-10

Coleman Mark

Director

5,193 @ $8.02$42K

Sell10b5-1

2026-02-02

TABUTEAU HERRIOT

Chief Executive Officer

32,410 @ $185.60$6.02M

Exercise10b5-1

2026-02-02

TABUTEAU HERRIOT

Chief Executive Officer

32,410 @ $8.02$260K

Sell10b5-1

2026-01-22

Pizzie Nick

Chief Financial Officer

12,000 @ $187.92$2.26M

Exercise10b5-1

2026-01-22

Pizzie Nick

Chief Financial Officer

12,000 @ $3.50$42K

Sell10b5-1

2026-01-21

Maizel Ari

Chief Commercial Officer

7,500 @ $184.44$1.38M

Exercise10b5-1

2026-01-21

Maizel Ari

Chief Commercial Officer

7,500 @ $70.73$530K

Exercise10b5-1

2026-01-07

TABUTEAU HERRIOT

Chief Executive Officer

31,261 @ $8.02$251K

Sell10b5-1

2026-01-07

TABUTEAU HERRIOT

Chief Executive Officer

31,261 @ $170.38$5.33M

Sell10b5-1

2026-01-06

TABUTEAU HERRIOT

Chief Executive Officer

29,450 @ $172.33$5.08M

Exercise10b5-1

2026-01-06

TABUTEAU HERRIOT

Chief Executive Officer

29,450 @ $8.02$236K

Exercise10b5-1

2026-01-05

TABUTEAU HERRIOT

Chief Executive Officer

78,703 @ $8.02$631K

Sell10b5-1

2026-01-05

TABUTEAU HERRIOT

Chief Executive Officer

78,703 @ $171.28$13.48M

Sell10b5-1

2025-12-31

Saad Mark E

Director

6,231 @ $165.18$1.03M

Exercise10b5-1

2025-12-31

Saad Mark E

Director

31,346 @ $4.95$155K

Sell10b5-1

2025-12-31

Saad Mark E

Director

31,346 @ $165.18$5.18M

Exercise10b5-1

2025-12-31

Saad Mark E

Director

6,231 @ $8.02$50K

Sell10b5-1

2025-12-04

TABUTEAU HERRIOT

Chief Executive Officer

10,558 @ $148.18$1.56M

Exercise10b5-1

2025-12-04

TABUTEAU HERRIOT

Chief Executive Officer

10,558 @ $8.02$85K

Sell10b5-1

2025-12-03

TABUTEAU HERRIOT

Chief Executive Officer

20,163 @ $146.94$2.96M

Exercise10b5-1

2025-12-03

TABUTEAU HERRIOT

Chief Executive Officer

20,163 @ $8.02$162K

Exercise10b5-1

2025-12-02

TABUTEAU HERRIOT

Chief Executive Officer

49,252 @ $8.02$395K

Sell10b5-1

2025-12-02

TABUTEAU HERRIOT

Chief Executive Officer

49,252 @ $144.59$7.12M

Sell10b5-1

2025-11-05

TABUTEAU HERRIOT

Chief Executive Officer

21,775 @ $134.49$2.93M

Exercise10b5-1

2025-11-05

TABUTEAU HERRIOT

Chief Executive Officer

21,775 @ $8.02$175K

Sell10b5-1

2025-11-04

TABUTEAU HERRIOT

Chief Executive Officer

50,459 @ $133.79$6.75M

Exercise10b5-1

2025-11-04

TABUTEAU HERRIOT

Chief Executive Officer

50,459 @ $8.02$405K

Sell10b5-1

2025-11-03

TABUTEAU HERRIOT

Chief Executive Officer

91,705 @ $132.34$12.14M

Exercise10b5-1

2025-11-03

TABUTEAU HERRIOT

Chief Executive Officer

91,705 @ $8.02$735K

Sell10b5-1

2025-10-08

TABUTEAU HERRIOT

Chief Executive Officer

12,774 @ $118.84$1.52M

Exercise10b5-1

2025-10-08

TABUTEAU HERRIOT

Chief Executive Officer

12,774 @ $8.02$102K

Sell10b5-1

2025-10-07

TABUTEAU HERRIOT

Chief Executive Officer

13,390 @ $118.77$1.59M

Exercise10b5-1

2025-10-07

TABUTEAU HERRIOT

Chief Executive Officer

13,390 @ $8.02$107K

Exercise10b5-1

2025-10-06

TABUTEAU HERRIOT

Chief Executive Officer

19,220 @ $8.02$154K

Sell10b5-1

2025-10-06

TABUTEAU HERRIOT

Chief Executive Officer

19,220 @ $120.17$2.31M

Date	Insider	Action	Shares	Price	Value
2026-02-26	Jacobson Mark L.Chief Operating Officer	Sell10b5-1	35,378	$161.88	$5.73M
2026-02-26	Jacobson Mark L.Chief Operating Officer	Grant	19,663	—	—
2026-02-26	Pizzie NickChief Financial Officer	Grant	18,570	—	—
2026-02-26	Murdock Hunter R.General Counsel	Grant	16,385	—	—
2026-02-26	Jacobson Mark L.Chief Operating Officer	Exercise10b5-1	35,378	$2.85	$101K
2026-02-26	TABUTEAU HERRIOTChief Executive Officer	Grant	54,623	—	—
2026-02-26	Maizel AriChief Commercial Officer	Grant	16,385	—	—
2026-02-26	Coleman MarkDirector	Sell10b5-1	25,000	$161.11	$4.03M
2026-02-23	Coleman MarkDirector	Exercise	6,250	$4.95	$31K
2026-02-20	Coleman MarkDirector	Exercise	12,485	$4.95	$62K
2026-02-10	Coleman MarkDirector	Exercise	5,193	$8.02	$42K
2026-02-02	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	32,410	$185.60	$6.02M
2026-02-02	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	32,410	$8.02	$260K
2026-01-22	Pizzie NickChief Financial Officer	Sell10b5-1	12,000	$187.92	$2.26M
2026-01-22	Pizzie NickChief Financial Officer	Exercise10b5-1	12,000	$3.50	$42K
2026-01-21	Maizel AriChief Commercial Officer	Sell10b5-1	7,500	$184.44	$1.38M
2026-01-21	Maizel AriChief Commercial Officer	Exercise10b5-1	7,500	$70.73	$530K
2026-01-07	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	31,261	$8.02	$251K
2026-01-07	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	31,261	$170.38	$5.33M
2026-01-06	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	29,450	$172.33	$5.08M
2026-01-06	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	29,450	$8.02	$236K
2026-01-05	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	78,703	$8.02	$631K
2026-01-05	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	78,703	$171.28	$13.48M
2025-12-31	Saad Mark EDirector	Sell10b5-1	6,231	$165.18	$1.03M
2025-12-31	Saad Mark EDirector	Exercise10b5-1	31,346	$4.95	$155K
2025-12-31	Saad Mark EDirector	Sell10b5-1	31,346	$165.18	$5.18M
2025-12-31	Saad Mark EDirector	Exercise10b5-1	6,231	$8.02	$50K
2025-12-04	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	10,558	$148.18	$1.56M
2025-12-04	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	10,558	$8.02	$85K
2025-12-03	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	20,163	$146.94	$2.96M
2025-12-03	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	20,163	$8.02	$162K
2025-12-02	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	49,252	$8.02	$395K
2025-12-02	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	49,252	$144.59	$7.12M
2025-11-05	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	21,775	$134.49	$2.93M
2025-11-05	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	21,775	$8.02	$175K
2025-11-04	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	50,459	$133.79	$6.75M
2025-11-04	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	50,459	$8.02	$405K
2025-11-03	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	91,705	$132.34	$12.14M
2025-11-03	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	91,705	$8.02	$735K
2025-10-08	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	12,774	$118.84	$1.52M
2025-10-08	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	12,774	$8.02	$102K
2025-10-07	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	13,390	$118.77	$1.59M
2025-10-07	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	13,390	$8.02	$107K
2025-10-06	TABUTEAU HERRIOTChief Executive Officer	Exercise10b5-1	19,220	$8.02	$154K
2025-10-06	TABUTEAU HERRIOTChief Executive Officer	Sell10b5-1	19,220	$120.17	$2.31M

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