PDUFAoutcome: unknownconf 0.98

vutrisiran — PDUFA

$ALNY · ALNYLAM PHARMACEUTICALS, INC.

Event date

July 14, 2022

1423 days ago

Sponsor runway

cash-flow +

$1.66B liquid

Evidence

“The updated Prescription Drug User Fee Act action date to allow for this review is July not14, 2022.”

Source: 8-K filed 2022-04-04View on EDGAR ↗0001193125-22-094409

Comparable historical pdufas· last 5 years · same event type

75% hit rate (3/4)

Ticker	Drug	Date	Outcome
$RCKT	kresladi	2026-03-28	success
$RYTM	imcivree	2026-03-20	success
$CYTK	aficamten	2025-12-26	unknown
$ALDX	reproxalap	2025-12-16	unknown
$BCRX	orladeyo	2025-12-12	success
$OMER	narsoplimab	2025-09-25	unknown
$BCRX	orladeyo (berotralstat)	2025-09-12	unknown
$ETON	et-400	2025-05-28	unknown
$ALDX	reproxalap	2025-04-02	failure
$IONS	olezarsen	2024-12-19	unknown

Recent insider activity· ±90 days

14 insiders · 0 buys · 16 sells

Grant

2022-08-22

Sigal Charles Elliott

Director

4,456 @ ——

Sell

2022-08-15

SHARP PHILLIP A

Director

11,600 @ $229.93$2.67M

Sell

2022-08-15

SHARP PHILLIP A

Director

1,218 @ $228.33$278K

Sell

2022-08-15

SHARP PHILLIP A

Director

3,853 @ $231.65$893K

Sell

2022-08-15

SHARP PHILLIP A

Director

715 @ $232.81$166K

Sell

2022-08-15

SHARP PHILLIP A

Director

98 @ $226.16$22K

Exercise

2022-08-15

SHARP PHILLIP A

Director

3,670 @ $63.86$234K

Exercise

2022-08-15

SHARP PHILLIP A

Director

30,000 @ $30.09$903K

Sell

2022-08-15

SHARP PHILLIP A

Director

16,186 @ $230.71$3.73M

Sell

2022-08-05

Tanguler Tolga

EVP, Chief Commercial Officer

149 @ $215.03$32K

Sell

2022-08-05

Tanguler Tolga

EVP, Chief Commercial Officer

541 @ $218.71$118K

Sell

2022-08-05

Tanguler Tolga

EVP, Chief Commercial Officer

99 @ $219.53$22K

Sell

2022-08-05

Tanguler Tolga

EVP, Chief Commercial Officer

105 @ $220.95$23K

Sell

2022-08-05

Tanguler Tolga

EVP, Chief Commercial Officer

398 @ $216.21$86K

Sell

2022-08-05

Tanguler Tolga

EVP, Chief Commercial Officer

440 @ $217.61$96K

Sell

2022-08-05

Tanguler Tolga

EVP, Chief Commercial Officer

5 @ $224.00$1K

Sell

2022-08-05

Tanguler Tolga

EVP, Chief Commercial Officer

104 @ $225.15$23K

Tax

2022-08-04

Garg Pushkal

EVP Chief R&D

4,603 @ $189.76$873K

Tax

2022-08-04

Greenstreet Yvonne

Chief Executive Officer

195 @ $209.83$41K

Tax

2022-08-04

Greenstreet Yvonne

Chief Executive Officer

194 @ $209.85$41K

Tax

2022-08-04

Greenstreet Yvonne

Chief Executive Officer

180 @ $210.25$38K

Tax

2022-08-04

Tanguler Tolga

EVP, Chief Commercial Officer

1,618 @ $189.76$307K

Tax

2022-08-04

Tanguler Tolga

EVP, Chief Commercial Officer

170 @ $210.50$36K

Tax

2022-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

4,573 @ $189.76$868K

Tax

2022-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

162 @ $209.83$34K

Tax

2022-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

146 @ $209.88$31K

Tax

2022-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

173 @ $210.50$36K

Tax

2022-08-04

Vaishnaw Akshay

President

5,479 @ $189.76$1.04M

Tax

2022-08-04

Vaishnaw Akshay

President

195 @ $210.22$41K

Tax

2022-08-04

Vaishnaw Akshay

President

180 @ $210.66$38K

Tax

2022-08-04

Vaishnaw Akshay

President

198 @ $210.75$42K

Tax

2022-08-04

Greenstreet Yvonne

Chief Executive Officer

5,433 @ $189.76$1.03M

Tax

2022-08-04

Garg Pushkal

EVP Chief R&D

165 @ $205.87$34K

Tax

2022-08-04

Garg Pushkal

EVP Chief R&D

172 @ $209.91$36K

Tax

2022-08-04

Garg Pushkal

EVP Chief R&D

146 @ $210.02$31K

Grant

2022-08-03

Vaishnaw Akshay

President

4,241 @ ——

Grant

2022-08-03

Vaishnaw Akshay

President

3,859 @ ——

Grant

2022-08-03

Poulton Jeffrey V.

EVP, Chief Financial Officer

3,109 @ ——

Grant

2022-08-03

Poulton Jeffrey V.

EVP, Chief Financial Officer

3,698 @ ——

Grant

2022-08-03

Poulton Jeffrey V.

EVP, Chief Financial Officer

4,518 @ ——

Sell

2022-08-03

Tanguler Tolga

EVP, Chief Commercial Officer

1,754 @ $210.00$368K

Grant

2022-08-03

Tanguler Tolga

EVP, Chief Commercial Officer

3,629 @ ——

Grant

2022-08-03

Greenstreet Yvonne

Chief Executive Officer

3,859 @ ——

Grant

2022-08-03

Greenstreet Yvonne

Chief Executive Officer

4,153 @ ——

Grant

2022-08-03

Greenstreet Yvonne

Chief Executive Officer

5,083 @ ——

Grant

2022-08-03

Garg Pushkal

EVP Chief R&D

4,518 @ ——

Grant

2022-08-03

Garg Pushkal

EVP Chief R&D

3,684 @ ——

Grant

2022-08-03

Garg Pushkal

EVP Chief R&D

3,109 @ ——

Grant

2022-08-03

Vaishnaw Akshay

President

5,083 @ ——

Sell

2022-07-05

Tanguler Tolga

EVP, Chief Commercial Officer

1,754 @ $150.00$263K

+ 8 more

Date	Insider	Action	Shares	Price	Value
2022-08-22	Sigal Charles ElliottDirector	Grant	4,456	—	—
2022-08-15	SHARP PHILLIP ADirector	Sell	11,600	$229.93	$2.67M
2022-08-15	SHARP PHILLIP ADirector	Sell	1,218	$228.33	$278K
2022-08-15	SHARP PHILLIP ADirector	Sell	3,853	$231.65	$893K
2022-08-15	SHARP PHILLIP ADirector	Sell	715	$232.81	$166K
2022-08-15	SHARP PHILLIP ADirector	Sell	98	$226.16	$22K
2022-08-15	SHARP PHILLIP ADirector	Exercise	3,670	$63.86	$234K
2022-08-15	SHARP PHILLIP ADirector	Exercise	30,000	$30.09	$903K
2022-08-15	SHARP PHILLIP ADirector	Sell	16,186	$230.71	$3.73M
2022-08-05	Tanguler TolgaEVP, Chief Commercial Officer	Sell	149	$215.03	$32K
2022-08-05	Tanguler TolgaEVP, Chief Commercial Officer	Sell	541	$218.71	$118K
2022-08-05	Tanguler TolgaEVP, Chief Commercial Officer	Sell	99	$219.53	$22K
2022-08-05	Tanguler TolgaEVP, Chief Commercial Officer	Sell	105	$220.95	$23K
2022-08-05	Tanguler TolgaEVP, Chief Commercial Officer	Sell	398	$216.21	$86K
2022-08-05	Tanguler TolgaEVP, Chief Commercial Officer	Sell	440	$217.61	$96K
2022-08-05	Tanguler TolgaEVP, Chief Commercial Officer	Sell	5	$224.00	$1K
2022-08-05	Tanguler TolgaEVP, Chief Commercial Officer	Sell	104	$225.15	$23K
2022-08-04	Garg PushkalEVP Chief R&D	Tax	4,603	$189.76	$873K
2022-08-04	Greenstreet YvonneChief Executive Officer	Tax	195	$209.83	$41K
2022-08-04	Greenstreet YvonneChief Executive Officer	Tax	194	$209.85	$41K
2022-08-04	Greenstreet YvonneChief Executive Officer	Tax	180	$210.25	$38K
2022-08-04	Tanguler TolgaEVP, Chief Commercial Officer	Tax	1,618	$189.76	$307K
2022-08-04	Tanguler TolgaEVP, Chief Commercial Officer	Tax	170	$210.50	$36K
2022-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Tax	4,573	$189.76	$868K
2022-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Tax	162	$209.83	$34K
2022-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Tax	146	$209.88	$31K
2022-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Tax	173	$210.50	$36K
2022-08-04	Vaishnaw AkshayPresident	Tax	5,479	$189.76	$1.04M
2022-08-04	Vaishnaw AkshayPresident	Tax	195	$210.22	$41K
2022-08-04	Vaishnaw AkshayPresident	Tax	180	$210.66	$38K
2022-08-04	Vaishnaw AkshayPresident	Tax	198	$210.75	$42K
2022-08-04	Greenstreet YvonneChief Executive Officer	Tax	5,433	$189.76	$1.03M
2022-08-04	Garg PushkalEVP Chief R&D	Tax	165	$205.87	$34K
2022-08-04	Garg PushkalEVP Chief R&D	Tax	172	$209.91	$36K
2022-08-04	Garg PushkalEVP Chief R&D	Tax	146	$210.02	$31K
2022-08-03	Vaishnaw AkshayPresident	Grant	4,241	—	—
2022-08-03	Vaishnaw AkshayPresident	Grant	3,859	—	—
2022-08-03	Poulton Jeffrey V.EVP, Chief Financial Officer	Grant	3,109	—	—
2022-08-03	Poulton Jeffrey V.EVP, Chief Financial Officer	Grant	3,698	—	—
2022-08-03	Poulton Jeffrey V.EVP, Chief Financial Officer	Grant	4,518	—	—
2022-08-03	Tanguler TolgaEVP, Chief Commercial Officer	Sell	1,754	$210.00	$368K
2022-08-03	Tanguler TolgaEVP, Chief Commercial Officer	Grant	3,629	—	—
2022-08-03	Greenstreet YvonneChief Executive Officer	Grant	3,859	—	—
2022-08-03	Greenstreet YvonneChief Executive Officer	Grant	4,153	—	—
2022-08-03	Greenstreet YvonneChief Executive Officer	Grant	5,083	—	—
2022-08-03	Garg PushkalEVP Chief R&D	Grant	4,518	—	—
2022-08-03	Garg PushkalEVP Chief R&D	Grant	3,684	—	—
2022-08-03	Garg PushkalEVP Chief R&D	Grant	3,109	—	—
2022-08-03	Vaishnaw AkshayPresident	Grant	5,083	—	—
2022-07-05	Tanguler TolgaEVP, Chief Commercial Officer	Sell	1,754	$150.00	$263K

+ 8 more transactions

← All catalysts for $ALNY