PDUFAconf 0.92

inclisiran — PDUFA

$ALNY · ALNYLAM PHARMACEUTICALS, INC. · elevated LDL-C / ASCVD

Event date

January 1, 2022

1617 days ago

Sponsor runway

cash-flow +

$1.66B liquid

Evidence

“Leqvio is now approved in more than 45 countries, with most awaiting reimbursement, and remains on track for U.S. launch with FDA action date of January 1, 2022.”

Source: Press release · 2021-10-28View press release ↗

Comparable historical pdufas· last 5 years · same event type

75% hit rate (3/4)

Ticker	Drug	Date	Outcome
$RCKT	kresladi	2026-03-28	success
$RYTM	imcivree	2026-03-20	success
$CYTK	aficamten	2025-12-26	unknown
$ALDX	reproxalap	2025-12-16	unknown
$BCRX	orladeyo	2025-12-12	success
$OMER	narsoplimab	2025-09-25	unknown
$BCRX	orladeyo (berotralstat)	2025-09-12	unknown
$ETON	et-400	2025-05-28	unknown
$ALDX	reproxalap	2025-04-02	failure
$IONS	olezarsen	2024-12-19	unknown

Recent insider activity· ±90 days

14 insiders · 0 buys · 30 sells

Sell

2022-04-01

PAUL STEVEN M

Director

253 @ $166.04$42K

Sell

2022-04-01

PAUL STEVEN M

Director

4,948 @ $168.95$836K

Sell

2022-04-01

PAUL STEVEN M

Director

4,872 @ $169.71$827K

Exercise

2022-04-01

PAUL STEVEN M

Director

15,000 @ $11.33$170K

Sell

2022-04-01

PAUL STEVEN M

Director

1,235 @ $171.16$211K

Sell

2022-04-01

PAUL STEVEN M

Director

1,434 @ $172.10$247K

Sell

2022-04-01

PAUL STEVEN M

Director

642 @ $173.06$111K

Sell

2022-04-01

PAUL STEVEN M

Director

90 @ $174.33$16K

Sell

2022-04-01

PAUL STEVEN M

Director

526 @ $176.51$93K

Sell

2022-04-01

PAUL STEVEN M

Director

825 @ $177.58$147K

Sell

2022-04-01

PAUL STEVEN M

Director

175 @ $178.60$31K

Grant

2022-02-23

Vaishnaw Akshay

President

29,842 @ ——

Grant

2022-02-23

Garg Pushkal

EVP Chief R&D

24,128 @ ——

Grant

2022-02-23

Tanguler Tolga

EVP, Chief Commercial Officer

18,413 @ ——

Grant

2022-02-23

Poulton Jeffrey V.

EVP, Chief Financial Officer

18,413 @ ——

Grant

2022-02-23

Greenstreet Yvonne

Chief Executive Officer

31,747 @ ——

Grant

2022-02-23

Fanucci Marsha

Director

136 @ ——

Grant

2022-02-23

Ausiello Dennis A

Director

136 @ ——

Grant

2022-02-23

HAMBURG MARGARET A

Director

136 @ ——

Grant

2022-02-23

SCHULMAN AMY W

Director

136 @ ——

Grant

2022-02-23

PYOTT DAVID E I

Director

136 @ ——

Sell

2022-02-09

SHARP PHILLIP A

Director

30,000 @ $150.00$4.50M

Exercise

2022-02-09

SHARP PHILLIP A

Director

30,000 @ $11.33$340K

Tax

2022-02-02

Tanguler Tolga

EVP, Chief Commercial Officer

1,518 @ $144.67$220K

Exercise

2022-02-01

Tanguler Tolga

EVP, Chief Commercial Officer

5,026 @ ——

Grant

2022-02-01

Franchini Indrani Lall

EVP, CLO & Secretary

15,525 @ ——

Grant

2022-02-01

Franchini Indrani Lall

EVP, CLO & Secretary

29,182 @ ——

Grant

2021-12-31

Greenstreet Yvonne

Chief Executive Officer

55,949 @ ——

Grant

2021-12-31

Vaishnaw Akshay

President

22,380 @ ——

Sell

2021-12-23

Vaishnaw Akshay

President

142 @ $190.39$27K

Sell

2021-12-23

Vaishnaw Akshay

President

124 @ $186.22$23K

Sell

2021-12-23

Vaishnaw Akshay

President

137 @ $187.08$26K

Sell

2021-12-23

Vaishnaw Akshay

President

130 @ $187.35$24K

Sell

2021-12-23

Vaishnaw Akshay

President

127 @ $188.26$24K

Sell

2021-12-23

Vaishnaw Akshay

President

73 @ $189.01$14K

Sell

2021-12-23

Vaishnaw Akshay

President

8 @ $189.18$2K

Sell

2021-12-23

Vaishnaw Akshay

President

144 @ $189.24$27K

Sell

2021-12-23

Vaishnaw Akshay

President

5 @ $190.27$951

Sell

2021-12-23

Vaishnaw Akshay

President

125 @ $190.86$24K

Sell

2021-12-23

Vaishnaw Akshay

President

1,000 @ $191.45$191K

Sell

2021-12-23

Vaishnaw Akshay

President

126 @ $193.37$24K

Sell

2021-12-23

Vaishnaw Akshay

President

145 @ $193.67$28K

Sell

2021-12-23

Vaishnaw Akshay

President

303 @ $195.11$59K

Tax

2021-12-22

Vaishnaw Akshay

President

1 @ $190.50$191

Tax

2021-12-22

Greenstreet Yvonne

Chief Executive Officer

1 @ $190.96$191

Tax

2021-12-22

Greenstreet Yvonne

Chief Executive Officer

122 @ $186.55$23K

Tax

2021-12-22

Greenstreet Yvonne

Chief Executive Officer

2,415 @ $189.13$457K

Tax

2021-12-22

Vaishnaw Akshay

President

2,415 @ $189.13$457K

Tax

2021-12-22

Vaishnaw Akshay

President

122 @ $186.48$23K

Tax

2021-12-22

MARAGANORE JOHN

Chief Executive Officer

6,315 @ $189.13$1.19M

+ 16 more

Date	Insider	Action	Shares	Price	Value
2022-04-01	PAUL STEVEN MDirector	Sell	253	$166.04	$42K
2022-04-01	PAUL STEVEN MDirector	Sell	4,948	$168.95	$836K
2022-04-01	PAUL STEVEN MDirector	Sell	4,872	$169.71	$827K
2022-04-01	PAUL STEVEN MDirector	Exercise	15,000	$11.33	$170K
2022-04-01	PAUL STEVEN MDirector	Sell	1,235	$171.16	$211K
2022-04-01	PAUL STEVEN MDirector	Sell	1,434	$172.10	$247K
2022-04-01	PAUL STEVEN MDirector	Sell	642	$173.06	$111K
2022-04-01	PAUL STEVEN MDirector	Sell	90	$174.33	$16K
2022-04-01	PAUL STEVEN MDirector	Sell	526	$176.51	$93K
2022-04-01	PAUL STEVEN MDirector	Sell	825	$177.58	$147K
2022-04-01	PAUL STEVEN MDirector	Sell	175	$178.60	$31K
2022-02-23	Vaishnaw AkshayPresident	Grant	29,842	—	—
2022-02-23	Garg PushkalEVP Chief R&D	Grant	24,128	—	—
2022-02-23	Tanguler TolgaEVP, Chief Commercial Officer	Grant	18,413	—	—
2022-02-23	Poulton Jeffrey V.EVP, Chief Financial Officer	Grant	18,413	—	—
2022-02-23	Greenstreet YvonneChief Executive Officer	Grant	31,747	—	—
2022-02-23	Fanucci MarshaDirector	Grant	136	—	—
2022-02-23	Ausiello Dennis ADirector	Grant	136	—	—
2022-02-23	HAMBURG MARGARET ADirector	Grant	136	—	—
2022-02-23	SCHULMAN AMY WDirector	Grant	136	—	—
2022-02-23	PYOTT DAVID E IDirector	Grant	136	—	—
2022-02-09	SHARP PHILLIP ADirector	Sell	30,000	$150.00	$4.50M
2022-02-09	SHARP PHILLIP ADirector	Exercise	30,000	$11.33	$340K
2022-02-02	Tanguler TolgaEVP, Chief Commercial Officer	Tax	1,518	$144.67	$220K
2022-02-01	Tanguler TolgaEVP, Chief Commercial Officer	Exercise	5,026	—	—
2022-02-01	Franchini Indrani LallEVP, CLO & Secretary	Grant	15,525	—	—
2022-02-01	Franchini Indrani LallEVP, CLO & Secretary	Grant	29,182	—	—
2021-12-31	Greenstreet YvonneChief Executive Officer	Grant	55,949	—	—
2021-12-31	Vaishnaw AkshayPresident	Grant	22,380	—	—
2021-12-23	Vaishnaw AkshayPresident	Sell	142	$190.39	$27K
2021-12-23	Vaishnaw AkshayPresident	Sell	124	$186.22	$23K
2021-12-23	Vaishnaw AkshayPresident	Sell	137	$187.08	$26K
2021-12-23	Vaishnaw AkshayPresident	Sell	130	$187.35	$24K
2021-12-23	Vaishnaw AkshayPresident	Sell	127	$188.26	$24K
2021-12-23	Vaishnaw AkshayPresident	Sell	73	$189.01	$14K
2021-12-23	Vaishnaw AkshayPresident	Sell	8	$189.18	$2K
2021-12-23	Vaishnaw AkshayPresident	Sell	144	$189.24	$27K
2021-12-23	Vaishnaw AkshayPresident	Sell	5	$190.27	$951
2021-12-23	Vaishnaw AkshayPresident	Sell	125	$190.86	$24K
2021-12-23	Vaishnaw AkshayPresident	Sell	1,000	$191.45	$191K
2021-12-23	Vaishnaw AkshayPresident	Sell	126	$193.37	$24K
2021-12-23	Vaishnaw AkshayPresident	Sell	145	$193.67	$28K
2021-12-23	Vaishnaw AkshayPresident	Sell	303	$195.11	$59K
2021-12-22	Vaishnaw AkshayPresident	Tax	1	$190.50	$191
2021-12-22	Greenstreet YvonneChief Executive Officer	Tax	1	$190.96	$191
2021-12-22	Greenstreet YvonneChief Executive Officer	Tax	122	$186.55	$23K
2021-12-22	Greenstreet YvonneChief Executive Officer	Tax	2,415	$189.13	$457K
2021-12-22	Vaishnaw AkshayPresident	Tax	2,415	$189.13	$457K
2021-12-22	Vaishnaw AkshayPresident	Tax	122	$186.48	$23K
2021-12-22	MARAGANORE JOHNChief Executive Officer	Tax	6,315	$189.13	$1.19M

+ 16 more transactions

← All catalysts for $ALNY