PDUFAconf 0.98

patisiran — PDUFA

$ALNY · ALNYLAM PHARMACEUTICALS, INC. · cardiomyopathy of transthyretin-mediated (ATTR) amyloidosis

Event date

October 8, 2023

972 days ago

Sponsor runway

cash-flow +

$1.66B liquid

Evidence

“the FDA has set an action date of October 8, 2023 under the Prescription Drug User Fee Act.”

Source: Press release · 2023-06-30View press release ↗

Comparable historical pdufas· last 5 years · same event type

75% hit rate (3/4)

Ticker	Drug	Date	Outcome
$RCKT	kresladi	2026-03-28	success
$RYTM	imcivree	2026-03-20	success
$CYTK	aficamten	2025-12-26	unknown
$ALDX	reproxalap	2025-12-16	unknown
$BCRX	orladeyo	2025-12-12	success
$OMER	narsoplimab	2025-09-25	unknown
$BCRX	orladeyo (berotralstat)	2025-09-12	unknown
$ETON	et-400	2025-05-28	unknown
$ALDX	reproxalap	2025-04-02	failure
$IONS	olezarsen	2024-12-19	unknown

Recent insider activity· ±90 days

5 insiders · 0 buys · 35 sells

Sell10b5-1

2023-12-27

BONNEY MICHAEL W

Director

30,000 @ $195.00$5.85M

Exercise10b5-1

2023-12-27

BONNEY MICHAEL W

Director

30,000 @ $96.45$2.89M

Sell

2023-08-07

Garg Pushkal

EVP Chief R&D

240 @ $185.32$44K

Sell

2023-08-07

Garg Pushkal

EVP Chief R&D

3,112 @ $183.58$571K

Sell

2023-08-07

Garg Pushkal

EVP Chief R&D

814 @ $184.65$150K

Sell

2023-08-04

Garg Pushkal

EVP Chief R&D

15 @ $188.40$3K

Sell

2023-08-04

Garg Pushkal

EVP Chief R&D

164 @ $189.31$31K

Sell

2023-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

944 @ $186.39$176K

Sell

2023-08-04

Garg Pushkal

EVP Chief R&D

658 @ $184.70$122K

Sell

2023-08-04

Garg Pushkal

EVP Chief R&D

1,593 @ $185.54$296K

Sell

2023-08-04

Garg Pushkal

EVP Chief R&D

945 @ $186.39$176K

Sell

2023-08-04

Garg Pushkal

EVP Chief R&D

86 @ $187.37$16K

Sell

2023-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

1,593 @ $185.54$296K

Sell

2023-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

86 @ $187.37$16K

Sell

2023-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

15 @ $188.40$3K

Sell

2023-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

164 @ $189.31$31K

Sell

2023-08-04

Greenstreet Yvonne

Chief Executive Officer

771 @ $184.70$142K

Sell

2023-08-04

Greenstreet Yvonne

Chief Executive Officer

1,869 @ $185.54$347K

Sell

2023-08-04

Greenstreet Yvonne

Chief Executive Officer

1,107 @ $186.39$206K

Sell

2023-08-04

Greenstreet Yvonne

Chief Executive Officer

101 @ $187.37$19K

Sell

2023-08-04

Greenstreet Yvonne

Chief Executive Officer

17 @ $188.40$3K

Sell

2023-08-04

Greenstreet Yvonne

Chief Executive Officer

192 @ $189.31$36K

Sell

2023-08-04

Vaishnaw Akshay

President

771 @ $184.70$142K

Sell

2023-08-04

Vaishnaw Akshay

President

1,869 @ $185.54$347K

Sell

2023-08-04

Vaishnaw Akshay

President

1,107 @ $186.39$206K

Sell

2023-08-04

Vaishnaw Akshay

President

101 @ $187.37$19K

Sell

2023-08-04

Vaishnaw Akshay

President

17 @ $188.40$3K

Sell

2023-08-04

Vaishnaw Akshay

President

192 @ $189.31$36K

Sell

2023-08-04

Poulton Jeffrey V.

EVP, Chief Financial Officer

658 @ $184.70$122K

Grant

2023-08-03

Garg Pushkal

EVP Chief R&D

3,109 @ ——

Grant

2023-08-03

Poulton Jeffrey V.

EVP, Chief Financial Officer

4,518 @ ——

Grant

2023-08-03

Poulton Jeffrey V.

EVP, Chief Financial Officer

3,109 @ ——

Sell

2023-08-03

BONNEY MICHAEL W

Director

300 @ $181.08$54K

Grant

2023-08-03

Vaishnaw Akshay

President

5,082 @ ——

Grant

2023-08-03

Garg Pushkal

EVP Chief R&D

4,518 @ ——

Grant

2023-08-03

Vaishnaw Akshay

President

3,859 @ ——

Sell

2023-08-03

BONNEY MICHAEL W

Director

500 @ $182.45$91K

Sell

2023-08-03

BONNEY MICHAEL W

Director

560 @ $183.75$103K

Grant

2023-08-03

Greenstreet Yvonne

Chief Executive Officer

5,082 @ ——

Grant

2023-08-03

Greenstreet Yvonne

Chief Executive Officer

3,859 @ ——

Sell

2023-08-03

BONNEY MICHAEL W

Director

1,535 @ $184.89$284K

Sell

2023-08-03

BONNEY MICHAEL W

Director

1,714 @ $185.99$319K

Sell

2023-08-03

BONNEY MICHAEL W

Director

1,389 @ $187.04$260K

Sell

2023-08-03

BONNEY MICHAEL W

Director

450 @ $187.71$84K

Exercise

2023-08-02

BONNEY MICHAEL W

Director

22,477 @ ——

Date	Insider	Action	Shares	Price	Value
2023-12-27	BONNEY MICHAEL WDirector	Sell10b5-1	30,000	$195.00	$5.85M
2023-12-27	BONNEY MICHAEL WDirector	Exercise10b5-1	30,000	$96.45	$2.89M
2023-08-07	Garg PushkalEVP Chief R&D	Sell	240	$185.32	$44K
2023-08-07	Garg PushkalEVP Chief R&D	Sell	3,112	$183.58	$571K
2023-08-07	Garg PushkalEVP Chief R&D	Sell	814	$184.65	$150K
2023-08-04	Garg PushkalEVP Chief R&D	Sell	15	$188.40	$3K
2023-08-04	Garg PushkalEVP Chief R&D	Sell	164	$189.31	$31K
2023-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Sell	944	$186.39	$176K
2023-08-04	Garg PushkalEVP Chief R&D	Sell	658	$184.70	$122K
2023-08-04	Garg PushkalEVP Chief R&D	Sell	1,593	$185.54	$296K
2023-08-04	Garg PushkalEVP Chief R&D	Sell	945	$186.39	$176K
2023-08-04	Garg PushkalEVP Chief R&D	Sell	86	$187.37	$16K
2023-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Sell	1,593	$185.54	$296K
2023-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Sell	86	$187.37	$16K
2023-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Sell	15	$188.40	$3K
2023-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Sell	164	$189.31	$31K
2023-08-04	Greenstreet YvonneChief Executive Officer	Sell	771	$184.70	$142K
2023-08-04	Greenstreet YvonneChief Executive Officer	Sell	1,869	$185.54	$347K
2023-08-04	Greenstreet YvonneChief Executive Officer	Sell	1,107	$186.39	$206K
2023-08-04	Greenstreet YvonneChief Executive Officer	Sell	101	$187.37	$19K
2023-08-04	Greenstreet YvonneChief Executive Officer	Sell	17	$188.40	$3K
2023-08-04	Greenstreet YvonneChief Executive Officer	Sell	192	$189.31	$36K
2023-08-04	Vaishnaw AkshayPresident	Sell	771	$184.70	$142K
2023-08-04	Vaishnaw AkshayPresident	Sell	1,869	$185.54	$347K
2023-08-04	Vaishnaw AkshayPresident	Sell	1,107	$186.39	$206K
2023-08-04	Vaishnaw AkshayPresident	Sell	101	$187.37	$19K
2023-08-04	Vaishnaw AkshayPresident	Sell	17	$188.40	$3K
2023-08-04	Vaishnaw AkshayPresident	Sell	192	$189.31	$36K
2023-08-04	Poulton Jeffrey V.EVP, Chief Financial Officer	Sell	658	$184.70	$122K
2023-08-03	Garg PushkalEVP Chief R&D	Grant	3,109	—	—
2023-08-03	Poulton Jeffrey V.EVP, Chief Financial Officer	Grant	4,518	—	—
2023-08-03	Poulton Jeffrey V.EVP, Chief Financial Officer	Grant	3,109	—	—
2023-08-03	BONNEY MICHAEL WDirector	Sell	300	$181.08	$54K
2023-08-03	Vaishnaw AkshayPresident	Grant	5,082	—	—
2023-08-03	Garg PushkalEVP Chief R&D	Grant	4,518	—	—
2023-08-03	Vaishnaw AkshayPresident	Grant	3,859	—	—
2023-08-03	BONNEY MICHAEL WDirector	Sell	500	$182.45	$91K
2023-08-03	BONNEY MICHAEL WDirector	Sell	560	$183.75	$103K
2023-08-03	Greenstreet YvonneChief Executive Officer	Grant	5,082	—	—
2023-08-03	Greenstreet YvonneChief Executive Officer	Grant	3,859	—	—
2023-08-03	BONNEY MICHAEL WDirector	Sell	1,535	$184.89	$284K
2023-08-03	BONNEY MICHAEL WDirector	Sell	1,714	$185.99	$319K
2023-08-03	BONNEY MICHAEL WDirector	Sell	1,389	$187.04	$260K
2023-08-03	BONNEY MICHAEL WDirector	Sell	450	$187.71	$84K
2023-08-02	BONNEY MICHAEL WDirector	Exercise	22,477	—	—

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