NDA/BLA filedconf 0.95

olezarsen — NDA/BLA filed

$IONS · IONIS PHARMACEUTICALS INC · Familial chylomicronemia syndrome (FCS)

Event date

Date TBD

Sponsor runway

7 mo

$1.92B liquid

Evidence

“In June 2024, the FDA accepted our NDA for patients with FCS for Priority Review with a Prescription Drug User Fee Act, or PDUFA, date of December nbsp;19, 2024.”

Source: 8-K filed 2024-09-09View on EDGAR ↗0001193125-24-215939

Comparable historical nda/bla fileds· last 5 years · same event type

Ticker	Drug	Date	Outcome
$AXSM	—	2025-12-31	unknown
$RCKT	kresladi	2025-10-14	unknown
$ALDX	reproxalap	2025-07-17	unknown
$ETON	et-600	2025-07-08	unknown
$BCRX	orladeyo (berotralstat)	2025-05-14	unknown
$CORT	relacorilant	2025-03-03	unknown
$ALDX	reproxalap	2024-11-01	unknown
$AXSM	axs-07	2024-09-04	unknown
$RCKT	kresladi	2023-10-02	unknown
$GERN	imetelstat	2023-08-21	unknown

Recent insider activity· ±90 days

11 insiders · 0 buys · 27 sells

Exercise10b5-1

2026-05-14

Monia Brett P

Chief Executive Officer

3,220 @ $32.60$105K

Sell10b5-1

2026-05-14

Monia Brett P

Chief Executive Officer

3,220 @ $78.68$253K

Sell10b5-1

2026-05-13

Monia Brett P

Chief Executive Officer

1,316 @ $78.01$103K

Exercise10b5-1

2026-05-13

Monia Brett P

Chief Executive Officer

1,316 @ $32.60$43K

Exercise10b5-1

2026-05-04

LOSCALZO JOSEPH

Director

10,321 @ $41.08$424K

Sell10b5-1

2026-05-04

LOSCALZO JOSEPH

Director

59,508 @ $74.90$4.46M

Sell10b5-1

2026-05-04

LOSCALZO JOSEPH

Director

17,781 @ $75.58$1.34M

Exercise10b5-1

2026-05-04

LOSCALZO JOSEPH

Director

16,000 @ $42.88$686K

Exercise10b5-1

2026-05-04

LOSCALZO JOSEPH

Director

10,968 @ $38.06$417K

Exercise10b5-1

2026-05-04

LOSCALZO JOSEPH

Director

12,000 @ $40.05$481K

Exercise10b5-1

2026-05-01

KLEIN JOSEPH III

Director

10,111 @ $47.11$476K

Sell10b5-1

2026-05-01

KLEIN JOSEPH III

Director

1,431 @ $74.45$107K

Sell10b5-1

2026-05-01

KLEIN JOSEPH III

Director

8,680 @ $73.35$637K

Sell10b5-1

2026-04-28

Baroldi Joseph

EVP, Chief Business Officer

1,626 @ $71.79$117K

Sell

2026-04-16

Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

4,902 @ $75.17$368K

Sell

2026-04-16

Birchler Brian

EVP, Corp and Development Ops

973 @ $75.04$73K

Sell

2026-04-16

Baroldi Joseph

EVP, Chief Business Officer

5,619 @ $74.56$419K

Sell10b5-1

2026-04-15

PARSHALL B LYNNE

Director

4,466 @ $76.19$340K

Exercise

2026-04-15

Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

12,226 @ ——

Exercise

2026-04-15

Baroldi Joseph

EVP, Chief Business Officer

10,837 @ ——

Sell10b5-1

2026-04-15

PARSHALL B LYNNE

Director

534 @ $76.97$41K

Exercise

2026-04-15

Birchler Brian

EVP, Corp and Development Ops

1,875 @ ——

Sell10b5-1

2026-04-02

Devers Shannon L.

EVP, Chief Human Resources Ofc

6,193 @ $74.05$459K

Sell10b5-1

2026-04-01

KLEIN JOSEPH III

Director

2,216 @ $75.95$168K

Sell10b5-1

2026-04-01

KLEIN JOSEPH III

Director

20,105 @ $75.50$1.52M

Exercise10b5-1

2026-04-01

KLEIN JOSEPH III

Director

10,321 @ $41.08$424K

Exercise10b5-1

2026-04-01

KLEIN JOSEPH III

Director

12,000 @ $38.06$457K

Sell10b5-1

2026-03-19

Schneider Eugene

EVP, Chf Clinical Develop Ofcr

5,812 @ $70.97$412K

Sell10b5-1

2026-03-17

HOUGEN ELIZABETH L

EVP, Finance & CFO

10,172 @ $73.21$745K

Exercise10b5-1

2026-03-16

HOUGEN ELIZABETH L

EVP, Finance & CFO

20,541 @ $37.58$772K

Exercise10b5-1

2026-03-16

HOUGEN ELIZABETH L

EVP, Finance & CFO

60,299 @ $60.89$3.67M

Exercise10b5-1

2026-03-16

HOUGEN ELIZABETH L

EVP, Finance & CFO

61,041 @ $56.78$3.47M

Sell10b5-1

2026-03-16

HOUGEN ELIZABETH L

EVP, Finance & CFO

9,440 @ $72.77$687K

Sell10b5-1

2026-03-16

HOUGEN ELIZABETH L

EVP, Finance & CFO

205,608 @ $72.38$14.88M

Exercise10b5-1

2026-03-16

HOUGEN ELIZABETH L

EVP, Finance & CFO

33,118 @ $32.60$1.08M

Sell10b5-1

2026-03-10

Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

16,086 @ $76.30$1.23M

Exercise10b5-1

2026-03-10

Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

4,675 @ $34.69$162K

Sell10b5-1

2026-03-10

Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

21,191 @ $75.50$1.60M

Exercise10b5-1

2026-03-10

Jenne Kyle

EVP, Chf GL Pdt Str Ofcr

32,602 @ $46.10$1.50M

Sell10b5-1

2026-03-10

Monia Brett P

Chief Executive Officer

17,591 @ $76.34$1.34M

Sell10b5-1

2026-03-10

Monia Brett P

Chief Executive Officer

16,512 @ $75.47$1.25M

Exercise10b5-1

2026-03-10

Monia Brett P

Chief Executive Officer

34,103 @ $60.89$2.08M

Sell10b5-1

2026-03-09

O'NEIL PATRICK R.

EVP CLO & General Counsel

10,148 @ $75.25$764K

Exercise10b5-1

2026-03-09

Monia Brett P

Chief Executive Officer

73,529 @ $60.89$4.48M

Exercise10b5-1

2026-03-09

Monia Brett P

Chief Executive Officer

40,822 @ $60.89$2.49M

Sell10b5-1

2026-03-09

Monia Brett P

Chief Executive Officer

7,382 @ $74.11$547K

Sell10b5-1

2026-03-09

Monia Brett P

Chief Executive Officer

117,604 @ $75.26$8.85M

Sell10b5-1

2026-03-09

Monia Brett P

Chief Executive Officer

1,684 @ $75.58$127K

Date	Insider	Action	Shares	Price	Value
2026-05-14	Monia Brett PChief Executive Officer	Exercise10b5-1	3,220	$32.60	$105K
2026-05-14	Monia Brett PChief Executive Officer	Sell10b5-1	3,220	$78.68	$253K
2026-05-13	Monia Brett PChief Executive Officer	Sell10b5-1	1,316	$78.01	$103K
2026-05-13	Monia Brett PChief Executive Officer	Exercise10b5-1	1,316	$32.60	$43K
2026-05-04	LOSCALZO JOSEPHDirector	Exercise10b5-1	10,321	$41.08	$424K
2026-05-04	LOSCALZO JOSEPHDirector	Sell10b5-1	59,508	$74.90	$4.46M
2026-05-04	LOSCALZO JOSEPHDirector	Sell10b5-1	17,781	$75.58	$1.34M
2026-05-04	LOSCALZO JOSEPHDirector	Exercise10b5-1	16,000	$42.88	$686K
2026-05-04	LOSCALZO JOSEPHDirector	Exercise10b5-1	10,968	$38.06	$417K
2026-05-04	LOSCALZO JOSEPHDirector	Exercise10b5-1	12,000	$40.05	$481K
2026-05-01	KLEIN JOSEPH IIIDirector	Exercise10b5-1	10,111	$47.11	$476K
2026-05-01	KLEIN JOSEPH IIIDirector	Sell10b5-1	1,431	$74.45	$107K
2026-05-01	KLEIN JOSEPH IIIDirector	Sell10b5-1	8,680	$73.35	$637K
2026-04-28	Baroldi JosephEVP, Chief Business Officer	Sell10b5-1	1,626	$71.79	$117K
2026-04-16	Jenne KyleEVP, Chf GL Pdt Str Ofcr	Sell	4,902	$75.17	$368K
2026-04-16	Birchler BrianEVP, Corp and Development Ops	Sell	973	$75.04	$73K
2026-04-16	Baroldi JosephEVP, Chief Business Officer	Sell	5,619	$74.56	$419K
2026-04-15	PARSHALL B LYNNEDirector	Sell10b5-1	4,466	$76.19	$340K
2026-04-15	Jenne KyleEVP, Chf GL Pdt Str Ofcr	Exercise	12,226	—	—
2026-04-15	Baroldi JosephEVP, Chief Business Officer	Exercise	10,837	—	—
2026-04-15	PARSHALL B LYNNEDirector	Sell10b5-1	534	$76.97	$41K
2026-04-15	Birchler BrianEVP, Corp and Development Ops	Exercise	1,875	—	—
2026-04-02	Devers Shannon L.EVP, Chief Human Resources Ofc	Sell10b5-1	6,193	$74.05	$459K
2026-04-01	KLEIN JOSEPH IIIDirector	Sell10b5-1	2,216	$75.95	$168K
2026-04-01	KLEIN JOSEPH IIIDirector	Sell10b5-1	20,105	$75.50	$1.52M
2026-04-01	KLEIN JOSEPH IIIDirector	Exercise10b5-1	10,321	$41.08	$424K
2026-04-01	KLEIN JOSEPH IIIDirector	Exercise10b5-1	12,000	$38.06	$457K
2026-03-19	Schneider EugeneEVP, Chf Clinical Develop Ofcr	Sell10b5-1	5,812	$70.97	$412K
2026-03-17	HOUGEN ELIZABETH LEVP, Finance & CFO	Sell10b5-1	10,172	$73.21	$745K
2026-03-16	HOUGEN ELIZABETH LEVP, Finance & CFO	Exercise10b5-1	20,541	$37.58	$772K
2026-03-16	HOUGEN ELIZABETH LEVP, Finance & CFO	Exercise10b5-1	60,299	$60.89	$3.67M
2026-03-16	HOUGEN ELIZABETH LEVP, Finance & CFO	Exercise10b5-1	61,041	$56.78	$3.47M
2026-03-16	HOUGEN ELIZABETH LEVP, Finance & CFO	Sell10b5-1	9,440	$72.77	$687K
2026-03-16	HOUGEN ELIZABETH LEVP, Finance & CFO	Sell10b5-1	205,608	$72.38	$14.88M
2026-03-16	HOUGEN ELIZABETH LEVP, Finance & CFO	Exercise10b5-1	33,118	$32.60	$1.08M
2026-03-10	Jenne KyleEVP, Chf GL Pdt Str Ofcr	Sell10b5-1	16,086	$76.30	$1.23M
2026-03-10	Jenne KyleEVP, Chf GL Pdt Str Ofcr	Exercise10b5-1	4,675	$34.69	$162K
2026-03-10	Jenne KyleEVP, Chf GL Pdt Str Ofcr	Sell10b5-1	21,191	$75.50	$1.60M
2026-03-10	Jenne KyleEVP, Chf GL Pdt Str Ofcr	Exercise10b5-1	32,602	$46.10	$1.50M
2026-03-10	Monia Brett PChief Executive Officer	Sell10b5-1	17,591	$76.34	$1.34M
2026-03-10	Monia Brett PChief Executive Officer	Sell10b5-1	16,512	$75.47	$1.25M
2026-03-10	Monia Brett PChief Executive Officer	Exercise10b5-1	34,103	$60.89	$2.08M
2026-03-09	O'NEIL PATRICK R.EVP CLO & General Counsel	Sell10b5-1	10,148	$75.25	$764K
2026-03-09	Monia Brett PChief Executive Officer	Exercise10b5-1	73,529	$60.89	$4.48M
2026-03-09	Monia Brett PChief Executive Officer	Exercise10b5-1	40,822	$60.89	$2.49M
2026-03-09	Monia Brett PChief Executive Officer	Sell10b5-1	7,382	$74.11	$547K
2026-03-09	Monia Brett PChief Executive Officer	Sell10b5-1	117,604	$75.26	$8.85M
2026-03-09	Monia Brett PChief Executive Officer	Sell10b5-1	1,684	$75.58	$127K

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