FDA approvalconf 0.97

teplizumab — FDA approval

$MGNX · MACROGENICS INC · first indication in the United States (anti-CD3 monoclonal antibody)

Event date

November 17, 2022

1297 days ago

Sponsor runway

6 mo

$66.5M liquid

Evidence

“On November 17, 2022, MacroGenics, Inc. (the ”

Source: 8-K filed 2022-11-18View on EDGAR ↗0001125345-22-000108

Comparable historical fda approvals· last 5 years · same event type

100% hit rate (10/10)

Ticker	Drug	Date	Outcome
$INCY	zynyz	2026-05-18	success
$INCY	jakafi xr	2026-05-01	success
$AXSM	auvelity	2026-04-30	success
$INCY	zynyz	2026-03-30	success
$BIIB	spinraza	2026-03-27	success
$CORT	lifyorli	2026-03-25	success
$RYTM	imcivree	2026-03-19	success
$ASND	yuviwel	2026-02-27	success
$BMRN	palynziq	2026-02-27	success
$ETON	desmoda	2026-02-25	success

Recent insider activity· ±90 days

11 insiders · 9 buys · 0 sells

Grant

2023-02-15

Spitznagel Thomas

Sr VP, Technical Ops

170,000 @ ——

Grant

2023-02-15

Spitznagel Thomas

Sr VP, Technical Ops

40,000 @ ——

Grant

2023-02-15

Eck Stephen L.

Chief Medical Officer

200,000 @ ——

Grant

2023-02-15

Eck Stephen L.

Chief Medical Officer

50,000 @ ——

Grant

2023-02-15

Koenig Scott

Director

510,000 @ ——

Grant

2023-02-15

Koenig Scott

Director

127,000 @ ——

Grant

2023-02-15

Cilinski Lynn

VP, Controller and Treasurer

75,000 @ ——

Grant

2023-02-15

Cilinski Lynn

VP, Controller and Treasurer

20,000 @ ——

Grant

2023-02-15

Risser Eric Blasius

President and CEO

200,000 @ ——

Grant

2023-02-15

Risser Eric Blasius

President and CEO

50,000 @ ——

Grant

2023-02-15

Karrels James

SVP and CFO

180,000 @ ——

Grant

2023-02-15

Karrels James

SVP and CFO

45,000 @ ——

Grant

2023-02-15

Peters Jeffrey Stuart

Senior VP, GC, and Secretary

170,000 @ ——

Grant

2023-02-15

Peters Jeffrey Stuart

Senior VP, GC, and Secretary

40,000 @ ——

Grant

2023-02-15

Bonvini Ezio

Sr VP, Research & CSO

200,000 @ ——

Grant

2023-02-15

Bonvini Ezio

Sr VP, Research & CSO

50,000 @ ——

Buy

2023-02-14

BIOTECH TARGET N V

10%+ Owner

500,000 @ $5.07$2.53M

Buy

2023-01-19

BIOTECH TARGET N V

10%+ Owner

150,000 @ $5.30$795K

Grant

2023-01-03

Liu Margaret

Director

36,000 @ ——

Grant

2023-01-03

Chhabra Meenu

Director

36,000 @ ——

Buy

2022-12-27

BIOTECH TARGET N V

10%+ Owner

200,000 @ $5.61$1.12M

Buy

2022-12-23

BIOTECH TARGET N V

10%+ Owner

200,000 @ $5.88$1.18M

Buy

2022-11-22

BIOTECH TARGET N V

10%+ Owner

300,000 @ $5.96$1.79M

Exercise

2022-10-28

Risser Eric Blasius

President and CEO

8,500 @ $1.51$13K

Buy

2022-10-24

BIOTECH TARGET N V

10%+ Owner

250,000 @ $4.36$1.09M

Buy

2022-10-21

BIOTECH TARGET N V

10%+ Owner

250,000 @ $4.63$1.16M

Buy

2022-10-20

BIOTECH TARGET N V

10%+ Owner

285,977 @ $4.00$1.14M

Buy

2022-10-19

BIOTECH TARGET N V

10%+ Owner

168,422 @ $3.70$624K

Date	Insider	Action	Shares	Price	Value
2023-02-15	Spitznagel ThomasSr VP, Technical Ops	Grant	170,000	—	—
2023-02-15	Spitznagel ThomasSr VP, Technical Ops	Grant	40,000	—	—
2023-02-15	Eck Stephen L.Chief Medical Officer	Grant	200,000	—	—
2023-02-15	Eck Stephen L.Chief Medical Officer	Grant	50,000	—	—
2023-02-15	Koenig ScottDirector	Grant	510,000	—	—
2023-02-15	Koenig ScottDirector	Grant	127,000	—	—
2023-02-15	Cilinski LynnVP, Controller and Treasurer	Grant	75,000	—	—
2023-02-15	Cilinski LynnVP, Controller and Treasurer	Grant	20,000	—	—
2023-02-15	Risser Eric BlasiusPresident and CEO	Grant	200,000	—	—
2023-02-15	Risser Eric BlasiusPresident and CEO	Grant	50,000	—	—
2023-02-15	Karrels JamesSVP and CFO	Grant	180,000	—	—
2023-02-15	Karrels JamesSVP and CFO	Grant	45,000	—	—
2023-02-15	Peters Jeffrey StuartSenior VP, GC, and Secretary	Grant	170,000	—	—
2023-02-15	Peters Jeffrey StuartSenior VP, GC, and Secretary	Grant	40,000	—	—
2023-02-15	Bonvini EzioSr VP, Research & CSO	Grant	200,000	—	—
2023-02-15	Bonvini EzioSr VP, Research & CSO	Grant	50,000	—	—
2023-02-14	BIOTECH TARGET N V10%+ Owner	Buy	500,000	$5.07	$2.53M
2023-01-19	BIOTECH TARGET N V10%+ Owner	Buy	150,000	$5.30	$795K
2023-01-03	Liu MargaretDirector	Grant	36,000	—	—
2023-01-03	Chhabra MeenuDirector	Grant	36,000	—	—
2022-12-27	BIOTECH TARGET N V10%+ Owner	Buy	200,000	$5.61	$1.12M
2022-12-23	BIOTECH TARGET N V10%+ Owner	Buy	200,000	$5.88	$1.18M
2022-11-22	BIOTECH TARGET N V10%+ Owner	Buy	300,000	$5.96	$1.79M
2022-10-28	Risser Eric BlasiusPresident and CEO	Exercise	8,500	$1.51	$13K
2022-10-24	BIOTECH TARGET N V10%+ Owner	Buy	250,000	$4.36	$1.09M
2022-10-21	BIOTECH TARGET N V10%+ Owner	Buy	250,000	$4.63	$1.16M
2022-10-20	BIOTECH TARGET N V10%+ Owner	Buy	285,977	$4.00	$1.14M
2022-10-19	BIOTECH TARGET N V10%+ Owner	Buy	168,422	$3.70	$624K

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