FDA approvaloutcome: successconf 1.00

palynziq — FDA approval

$BMRN · BIOMARIN PHARMACEUTICAL INC

Event date

February 27, 2026

99 days ago

Sponsor runway

cash-flow +

$2.22B liquid

Evidence

“openFDA SUPPL (EFFICACY) approval of PALYNZIQ — application BLA761079”

Source ↗

Comparable historical fda approvals· last 5 years · same event type

100% hit rate (10/10)

Ticker	Drug	Date	Outcome
$INCY	zynyz	2026-05-18	success
$INCY	jakafi xr	2026-05-01	success
$AXSM	auvelity	2026-04-30	success
$INCY	zynyz	2026-03-30	success
$BIIB	spinraza	2026-03-27	success
$CORT	lifyorli	2026-03-25	success
$RYTM	imcivree	2026-03-19	success
$ASND	yuviwel	2026-02-27	success
$ETON	desmoda	2026-02-25	success
$JAZZ	vyxeos	2026-01-27	success

Recent insider activity· ±90 days

7 insiders · 0 buys · 4 sells

Tax

2026-05-20

Hubbard Cristin

EVP, Chief Commercial Officer

2,318 @ $50.20$116K

Sell

2026-05-07

Friberg Gregory R

EVP, Chief R&D Officer

3,281 @ $53.85$177K

Tax

2026-03-18

Davis George Eric

EVP, Chief Legal Officer

1,273 @ $56.05$71K

Tax

2026-03-17

Hubbard Cristin

EVP, Chief Commercial Officer

1,245 @ $56.05$70K

Tax

2026-03-17

Friberg Gregory R

EVP, Chief R&D Officer

1,629 @ $56.05$91K

Tax

2026-03-17

Guyer Charles Greg

EVP, Chief Technical Officer

1,693 @ $56.05$95K

Tax

2026-03-17

Mueller Brian

EVP, Chief Financial Officer

2,117 @ $56.05$119K

Tax

2026-03-17

Hardy Alexander

Chief Executive Officer

4,252 @ $56.05$238K

Grant

2026-03-16

Davis George Eric

EVP, Chief Legal Officer

14,570 @ ——

Grant

2026-03-16

Davis George Eric

EVP, Chief Legal Officer

34,690 @ ——

Grant

2026-03-16

Mueller Brian

EVP, Chief Financial Officer

44,600 @ ——

Grant

2026-03-16

Hubbard Cristin

EVP, Chief Commercial Officer

15,410 @ ——

Grant

2026-03-16

Hubbard Cristin

EVP, Chief Commercial Officer

36,680 @ ——

Grant

2026-03-16

Friberg Gregory R

EVP, Chief R&D Officer

19,150 @ ——

Grant

2026-03-16

Friberg Gregory R

EVP, Chief R&D Officer

45,600 @ ——

Grant

2026-03-16

Guyer Charles Greg

EVP, Chief Technical Officer

14,990 @ ——

Grant

2026-03-16

Guyer Charles Greg

EVP, Chief Technical Officer

35,680 @ ——

Tax

2026-03-16

Davis George Eric

EVP, Chief Legal Officer

7,177 @ $58.51$420K

Grant

2026-03-16

Mueller Brian

EVP, Chief Financial Officer

18,740 @ ——

Grant

2026-03-16

Hardy Alexander

Chief Executive Officer

62,440 @ ——

Grant

2026-03-16

Hardy Alexander

Chief Executive Officer

89,200 @ ——

Tax

2026-03-13

Hardy Alexander

Chief Executive Officer

2,941 @ $58.51$172K

Tax

2026-03-13

Mueller Brian

EVP, Chief Financial Officer

9,945 @ $58.51$582K

Tax

2026-03-13

Guyer Charles Greg

EVP, Chief Technical Officer

9,109 @ $58.51$533K

Sell

2026-03-11

Guyer Charles Greg

EVP, Chief Technical Officer

16,486 @ $60.46$997K

Sell

2026-02-26

Davis George Eric

EVP, Chief Legal Officer

26,061 @ $61.36$1.60M

Sell

2026-02-26

Friberg Gregory R

EVP, Chief R&D Officer

6,326 @ $60.38$382K

Grant

2026-02-25

Guyer Charles Greg

EVP, Chief Technical Officer

6,675 @ ——

Grant

2026-02-25

Mueller Brian

EVP, Chief Financial Officer

6,683 @ ——

Grant

2026-02-25

Mueller Brian

EVP, Chief Financial Officer

7,230 @ ——

Grant

2026-02-25

Mueller Brian

EVP, Chief Financial Officer

2,569 @ ——

Grant

2026-02-25

Guyer Charles Greg

EVP, Chief Technical Officer

2,371 @ ——

Grant

2026-02-25

Davis George Eric

EVP, Chief Legal Officer

6,177 @ ——

Grant

2026-02-25

Davis George Eric

EVP, Chief Legal Officer

6,675 @ ——

Grant

2026-02-25

Davis George Eric

EVP, Chief Legal Officer

2,372 @ ——

Grant

2026-02-25

Guyer Charles Greg

EVP, Chief Technical Officer

6,176 @ ——

Grant

2026-01-20

Ramchandani Rashmi Virendra

VP, Chief Accounting Officer

18,220 @ ——

Grant

2026-01-20

Ramchandani Rashmi Virendra

VP, Chief Accounting Officer

18,540 @ ——

Grant

2026-01-20

Ramchandani Rashmi Virendra

VP, Chief Accounting Officer

7,070 @ ——

Tax

2025-12-01

Hardy Alexander

Chief Executive Officer

16,570 @ $55.03$912K

Date	Insider	Action	Shares	Price	Value
2026-05-20	Hubbard CristinEVP, Chief Commercial Officer	Tax	2,318	$50.20	$116K
2026-05-07	Friberg Gregory REVP, Chief R&D Officer	Sell	3,281	$53.85	$177K
2026-03-18	Davis George EricEVP, Chief Legal Officer	Tax	1,273	$56.05	$71K
2026-03-17	Hubbard CristinEVP, Chief Commercial Officer	Tax	1,245	$56.05	$70K
2026-03-17	Friberg Gregory REVP, Chief R&D Officer	Tax	1,629	$56.05	$91K
2026-03-17	Guyer Charles GregEVP, Chief Technical Officer	Tax	1,693	$56.05	$95K
2026-03-17	Mueller BrianEVP, Chief Financial Officer	Tax	2,117	$56.05	$119K
2026-03-17	Hardy AlexanderChief Executive Officer	Tax	4,252	$56.05	$238K
2026-03-16	Davis George EricEVP, Chief Legal Officer	Grant	14,570	—	—
2026-03-16	Davis George EricEVP, Chief Legal Officer	Grant	34,690	—	—
2026-03-16	Mueller BrianEVP, Chief Financial Officer	Grant	44,600	—	—
2026-03-16	Hubbard CristinEVP, Chief Commercial Officer	Grant	15,410	—	—
2026-03-16	Hubbard CristinEVP, Chief Commercial Officer	Grant	36,680	—	—
2026-03-16	Friberg Gregory REVP, Chief R&D Officer	Grant	19,150	—	—
2026-03-16	Friberg Gregory REVP, Chief R&D Officer	Grant	45,600	—	—
2026-03-16	Guyer Charles GregEVP, Chief Technical Officer	Grant	14,990	—	—
2026-03-16	Guyer Charles GregEVP, Chief Technical Officer	Grant	35,680	—	—
2026-03-16	Davis George EricEVP, Chief Legal Officer	Tax	7,177	$58.51	$420K
2026-03-16	Mueller BrianEVP, Chief Financial Officer	Grant	18,740	—	—
2026-03-16	Hardy AlexanderChief Executive Officer	Grant	62,440	—	—
2026-03-16	Hardy AlexanderChief Executive Officer	Grant	89,200	—	—
2026-03-13	Hardy AlexanderChief Executive Officer	Tax	2,941	$58.51	$172K
2026-03-13	Mueller BrianEVP, Chief Financial Officer	Tax	9,945	$58.51	$582K
2026-03-13	Guyer Charles GregEVP, Chief Technical Officer	Tax	9,109	$58.51	$533K
2026-03-11	Guyer Charles GregEVP, Chief Technical Officer	Sell	16,486	$60.46	$997K
2026-02-26	Davis George EricEVP, Chief Legal Officer	Sell	26,061	$61.36	$1.60M
2026-02-26	Friberg Gregory REVP, Chief R&D Officer	Sell	6,326	$60.38	$382K
2026-02-25	Guyer Charles GregEVP, Chief Technical Officer	Grant	6,675	—	—
2026-02-25	Mueller BrianEVP, Chief Financial Officer	Grant	6,683	—	—
2026-02-25	Mueller BrianEVP, Chief Financial Officer	Grant	7,230	—	—
2026-02-25	Mueller BrianEVP, Chief Financial Officer	Grant	2,569	—	—
2026-02-25	Guyer Charles GregEVP, Chief Technical Officer	Grant	2,371	—	—
2026-02-25	Davis George EricEVP, Chief Legal Officer	Grant	6,177	—	—
2026-02-25	Davis George EricEVP, Chief Legal Officer	Grant	6,675	—	—
2026-02-25	Davis George EricEVP, Chief Legal Officer	Grant	2,372	—	—
2026-02-25	Guyer Charles GregEVP, Chief Technical Officer	Grant	6,176	—	—
2026-01-20	Ramchandani Rashmi VirendraVP, Chief Accounting Officer	Grant	18,220	—	—
2026-01-20	Ramchandani Rashmi VirendraVP, Chief Accounting Officer	Grant	18,540	—	—
2026-01-20	Ramchandani Rashmi VirendraVP, Chief Accounting Officer	Grant	7,070	—	—
2025-12-01	Hardy AlexanderChief Executive Officer	Tax	16,570	$55.03	$912K

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