FDA approvaloutcome: successconf 1.00

zynyz — FDA approval

$INCY · INCYTE CORP

Event date

March 30, 2026

68 days ago

Sponsor runway

cash-flow +

$3.46B liquid

Evidence

“openFDA SUPPL (EFFICACY) approval of ZYNYZ — application BLA761334”

Source ↗

Comparable historical fda approvals· last 5 years · same event type

100% hit rate (10/10)

Ticker	Drug	Date	Outcome
$INCY	zynyz	2026-05-18	success
$INCY	jakafi xr	2026-05-01	success
$AXSM	auvelity	2026-04-30	success
$BIIB	spinraza	2026-03-27	success
$CORT	lifyorli	2026-03-25	success
$RYTM	imcivree	2026-03-19	success
$ASND	yuviwel	2026-02-27	success
$BMRN	palynziq	2026-02-27	success
$ETON	desmoda	2026-02-25	success
$JAZZ	vyxeos	2026-01-27	success

Recent insider activity· ±90 days

13 insiders · 0 buys · 6 sells

Sell10b5-1

2026-05-19

Clancy Paul J

Director

15,000 @ $94.93$1.42M

Exercise10b5-1

2026-05-19

Clancy Paul J

Director

15,000 @ $84.53$1.27M

Exercise

2026-05-08

BAKER BROS. ADVISORS LP

Director

15,000 @ $84.53$1.27M

Grant

2026-05-04

Upadhyay Suketu

EVP & Chief Financial Officer

38,429 @ ——

Grant

2026-05-04

Upadhyay Suketu

EVP & Chief Financial Officer

13,171 @ ——

Grant

2026-05-04

Upadhyay Suketu

EVP & Chief Financial Officer

26,343 @ ——

Exercise10b5-1

2026-04-17

CAGNONI PABLO J

President, Global Head of R&D

12,590 @ $71.93$906K

Exercise10b5-1

2026-04-17

CAGNONI PABLO J

President, Global Head of R&D

6,077 @ $64.25$390K

Sell10b5-1

2026-04-17

CAGNONI PABLO J

President, Global Head of R&D

18,667 @ $96.50$1.80M

Grant

2026-04-15

Stein Steven H

CMO & Head of Late-Stage Dev.

39,049 @ ——

Grant

2026-04-15

CAGNONI PABLO J

President, Global Head of R&D

27,892 @ ——

Exercise

2026-04-15

Meury William

Chief Executive Officer

125,000 @ ——

Grant

2026-03-31

Clancy Paul J

Director

265 @ $94.12$25K

Grant

2026-03-31

HARRIGAN EDMUND

Director

269 @ $94.12$25K

Grant

2026-03-31

BAKER BROS. ADVISORS LP

Director

421 @ ——

Tax

2026-03-25

Trotta Matteo

EVP, GM, Dermatology US

537 @ $92.23$50K

Exercise10b5-1

2026-03-17

CAGNONI PABLO J

President, Global Head of R&D

11,501 @ $64.25$739K

Sell10b5-1

2026-03-17

CAGNONI PABLO J

President, Global Head of R&D

18,667 @ $94.24$1.76M

Exercise10b5-1

2026-03-17

CAGNONI PABLO J

President, Global Head of R&D

7,166 @ $61.18$438K

Sell10b5-1

2026-02-19

CAGNONI PABLO J

President, Global Head of R&D

18,668 @ $100.91$1.88M

Exercise10b5-1

2026-02-19

CAGNONI PABLO J

President, Global Head of R&D

13,093 @ $61.76$809K

Exercise10b5-1

2026-02-19

CAGNONI PABLO J

President, Global Head of R&D

5,575 @ $61.18$341K

Tax

2026-02-02

Heeson Lee

EVP, Head of Incyte Intl

111 @ $102.67$11K

Tax

2026-02-02

Morrissey Michael James

EVP, Head of Tech. Operations

185 @ $102.67$19K

Tax

2026-01-20

Morrissey Michael James

EVP, Head of Tech. Operations

429 @ $102.62$44K

Grant

2026-01-16

Issa Mohamed Khairie

EVP, Head of US Oncology

14,237 @ ——

Grant

2026-01-16

Heeson Lee

EVP, Head of Incyte Intl

8,911 @ ——

Grant

2026-01-16

Stein Steven H

CMO & Head of Late-Stage Dev.

19,932 @ ——

Grant

2026-01-16

Trotta Matteo

EVP, GM, Dermatology US

8,542 @ ——

Grant

2026-01-16

CAGNONI PABLO J

President, Global Head of R&D

28,475 @ ——

Grant

2026-01-16

Mayes Patrick A

EVP & Chief Scientific Officer

4,218 @ ——

Grant

2026-01-16

Morrissey Michael James

EVP, Head of Tech. Operations

7,426 @ ——

Grant

2026-01-16

Tray Thomas

Principal Accounting Officer

2,425 @ ——

Sell10b5-1

2026-01-07

Issa Mohamed Khairie

EVP, Head of US Oncology

10,856 @ $109.07$1.18M

Tax10b5-1

2026-01-06

Issa Mohamed Khairie

EVP, Head of US Oncology

8,264 @ $106.66$881K

Sell10b5-1

2026-01-05

Stein Steven H

CMO & Head of Late-Stage Dev.

15,634 @ $101.70$1.59M

Tax

2025-12-31

Stein Steven H

CMO & Head of Late-Stage Dev.

13,292 @ $98.77$1.31M

Grant

2025-12-31

Clancy Paul J

Director

241 @ $98.77$24K

Tax

2025-12-31

Morrissey Michael James

EVP, Head of Tech. Operations

254 @ $98.77$25K

Grant

2025-12-31

HARRIGAN EDMUND

Director

245 @ $98.77$24K

Grant

2025-12-31

BAKER BROS. ADVISORS LP

Director

328 @ ——

Date	Insider	Action	Shares	Price	Value
2026-05-19	Clancy Paul JDirector	Sell10b5-1	15,000	$94.93	$1.42M
2026-05-19	Clancy Paul JDirector	Exercise10b5-1	15,000	$84.53	$1.27M
2026-05-08	BAKER BROS. ADVISORS LPDirector	Exercise	15,000	$84.53	$1.27M
2026-05-04	Upadhyay SuketuEVP & Chief Financial Officer	Grant	38,429	—	—
2026-05-04	Upadhyay SuketuEVP & Chief Financial Officer	Grant	13,171	—	—
2026-05-04	Upadhyay SuketuEVP & Chief Financial Officer	Grant	26,343	—	—
2026-04-17	CAGNONI PABLO JPresident, Global Head of R&D	Exercise10b5-1	12,590	$71.93	$906K
2026-04-17	CAGNONI PABLO JPresident, Global Head of R&D	Exercise10b5-1	6,077	$64.25	$390K
2026-04-17	CAGNONI PABLO JPresident, Global Head of R&D	Sell10b5-1	18,667	$96.50	$1.80M
2026-04-15	Stein Steven HCMO & Head of Late-Stage Dev.	Grant	39,049	—	—
2026-04-15	CAGNONI PABLO JPresident, Global Head of R&D	Grant	27,892	—	—
2026-04-15	Meury WilliamChief Executive Officer	Exercise	125,000	—	—
2026-03-31	Clancy Paul JDirector	Grant	265	$94.12	$25K
2026-03-31	HARRIGAN EDMUNDDirector	Grant	269	$94.12	$25K
2026-03-31	BAKER BROS. ADVISORS LPDirector	Grant	421	—	—
2026-03-25	Trotta MatteoEVP, GM, Dermatology US	Tax	537	$92.23	$50K
2026-03-17	CAGNONI PABLO JPresident, Global Head of R&D	Exercise10b5-1	11,501	$64.25	$739K
2026-03-17	CAGNONI PABLO JPresident, Global Head of R&D	Sell10b5-1	18,667	$94.24	$1.76M
2026-03-17	CAGNONI PABLO JPresident, Global Head of R&D	Exercise10b5-1	7,166	$61.18	$438K
2026-02-19	CAGNONI PABLO JPresident, Global Head of R&D	Sell10b5-1	18,668	$100.91	$1.88M
2026-02-19	CAGNONI PABLO JPresident, Global Head of R&D	Exercise10b5-1	13,093	$61.76	$809K
2026-02-19	CAGNONI PABLO JPresident, Global Head of R&D	Exercise10b5-1	5,575	$61.18	$341K
2026-02-02	Heeson LeeEVP, Head of Incyte Intl	Tax	111	$102.67	$11K
2026-02-02	Morrissey Michael JamesEVP, Head of Tech. Operations	Tax	185	$102.67	$19K
2026-01-20	Morrissey Michael JamesEVP, Head of Tech. Operations	Tax	429	$102.62	$44K
2026-01-16	Issa Mohamed KhairieEVP, Head of US Oncology	Grant	14,237	—	—
2026-01-16	Heeson LeeEVP, Head of Incyte Intl	Grant	8,911	—	—
2026-01-16	Stein Steven HCMO & Head of Late-Stage Dev.	Grant	19,932	—	—
2026-01-16	Trotta MatteoEVP, GM, Dermatology US	Grant	8,542	—	—
2026-01-16	CAGNONI PABLO JPresident, Global Head of R&D	Grant	28,475	—	—
2026-01-16	Mayes Patrick AEVP & Chief Scientific Officer	Grant	4,218	—	—
2026-01-16	Morrissey Michael JamesEVP, Head of Tech. Operations	Grant	7,426	—	—
2026-01-16	Tray ThomasPrincipal Accounting Officer	Grant	2,425	—	—
2026-01-07	Issa Mohamed KhairieEVP, Head of US Oncology	Sell10b5-1	10,856	$109.07	$1.18M
2026-01-06	Issa Mohamed KhairieEVP, Head of US Oncology	Tax10b5-1	8,264	$106.66	$881K
2026-01-05	Stein Steven HCMO & Head of Late-Stage Dev.	Sell10b5-1	15,634	$101.70	$1.59M
2025-12-31	Stein Steven HCMO & Head of Late-Stage Dev.	Tax	13,292	$98.77	$1.31M
2025-12-31	Clancy Paul JDirector	Grant	241	$98.77	$24K
2025-12-31	Morrissey Michael JamesEVP, Head of Tech. Operations	Tax	254	$98.77	$25K
2025-12-31	HARRIGAN EDMUNDDirector	Grant	245	$98.77	$24K
2025-12-31	BAKER BROS. ADVISORS LPDirector	Grant	328	—	—

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