FDA approvaloutcome: successconf 1.00

imcivree — FDA approval

$RYTM · RHYTHM PHARMACEUTICALS, INC.

Event date

March 19, 2026

79 days ago

Sponsor runway

23 mo

$340.6M liquid

Evidence

“openFDA SUPPL (EFFICACY) approval of IMCIVREE — application NDA213793”

Source ↗

Comparable historical fda approvals· last 5 years · same event type

100% hit rate (10/10)

Ticker	Drug	Date	Outcome
$INCY	zynyz	2026-05-18	success
$INCY	jakafi xr	2026-05-01	success
$AXSM	auvelity	2026-04-30	success
$INCY	zynyz	2026-03-30	success
$BIIB	spinraza	2026-03-27	success
$CORT	lifyorli	2026-03-25	success
$ASND	yuviwel	2026-02-27	success
$BMRN	palynziq	2026-02-27	success
$ETON	desmoda	2026-02-25	success
$JAZZ	vyxeos	2026-01-27	success

Recent insider activity· ±90 days

10 insiders · 0 buys · 24 sells

Exercise

2026-05-18

Smith Hunter C

Chief Financial Officer

3,000 @ $17.87$54K

Exercise

2026-05-15

German Christopher Paul

Corporate Controller & CAO

1,406 @ $17.97$25K

Sell

2026-05-15

German Christopher Paul

Corporate Controller & CAO

4,643 @ $92.21$428K

Exercise

2026-05-15

German Christopher Paul

Corporate Controller & CAO

1,349 @ $49.23$66K

Exercise

2026-05-15

German Christopher Paul

Corporate Controller & CAO

1,687 @ $56.69$96K

Exercise

2026-04-01

Mazabraud Yann

EVP, Head of International

10,375 @ ——

Exercise

2026-04-01

Mazabraud Yann

EVP, Head of International

2,500 @ ——

Grant

2026-04-01

Popovits Kimberly J

Director

6,808 @ ——

Grant

2026-04-01

Popovits Kimberly J

Director

10,257 @ ——

Exercise

2026-04-01

Mazabraud Yann

EVP, Head of International

12,875 @ ——

Other

2026-03-12

Mathers Edward T

Director

4,199 @ ——

Exercise

2026-03-04

German Christopher Paul

Corporate Controller & CAO

1,500 @ $17.97$27K

Sell

2026-03-04

German Christopher Paul

Corporate Controller & CAO

5,614 @ $89.56$503K

Other

2026-03-02

Mathers Edward T

Director

4,198 @ ——

Exercise

2026-03-02

Smith Hunter C

Chief Financial Officer

6,099 @ $6.80$41K

Grant

2026-03-02

Mazabraud Yann

EVP, Head of International

35,000 @ ——

Exercise

2026-03-01

German Christopher Paul

Corporate Controller & CAO

1,162 @ ——

Tax

2026-03-01

German Christopher Paul

Corporate Controller & CAO

342 @ $94.94$32K

Sell10b5-1

2026-02-19

Smith Hunter C

Chief Financial Officer

800 @ $102.10$82K

Sell10b5-1

2026-02-19

Smith Hunter C

Chief Financial Officer

1,308 @ $100.27$131K

Sell10b5-1

2026-02-19

Smith Hunter C

Chief Financial Officer

1,692 @ $100.92$171K

Sell10b5-1

2026-02-19

Smith Hunter C

Chief Financial Officer

585 @ $103.28$60K

Sell10b5-1

2026-02-17

Smith Hunter C

Chief Financial Officer

900 @ $101.70$92K

Sell10b5-1

2026-02-17

Smith Hunter C

Chief Financial Officer

1,069 @ $103.00$110K

Sell10b5-1

2026-02-17

Smith Hunter C

Chief Financial Officer

1,200 @ $99.42$119K

Sell10b5-1

2026-02-17

Smith Hunter C

Chief Financial Officer

200 @ $100.52$20K

Exercise

2026-02-14

Mazabraud Yann

EVP, Head of International

10,000 @ ——

Sell10b5-1

2026-02-12

Smith Hunter C

Chief Financial Officer

800 @ $98.99$79K

Sell10b5-1

2026-02-12

Smith Hunter C

Chief Financial Officer

292 @ $96.26$28K

Sell10b5-1

2026-02-12

Smith Hunter C

Chief Financial Officer

100 @ $100.10$10K

Sell10b5-1

2026-02-12

Smith Hunter C

Chief Financial Officer

400 @ $97.67$39K

Grant

2026-02-11

Lee Jennifer Kayden

EVP, Head of North America

32,500 @ ——

Grant

2026-02-11

Shulman Joseph

Chief Technical Officer

15,000 @ ——

Grant

2026-02-11

Shulman Joseph

Chief Technical Officer

22,500 @ ——

Grant

2026-02-11

Meeker David P

President and CEO

71,900 @ ——

Grant

2026-02-11

Meeker David P

President and CEO

107,850 @ ——

Grant

2026-02-11

Mazabraud Yann

EVP, Head of International

23,350 @ ——

Grant

2026-02-11

Lee Jennifer Kayden

EVP, Head of North America

21,650 @ ——

Grant

2026-02-11

German Christopher Paul

Corporate Controller & CAO

5,215 @ ——

Grant

2026-02-11

Garfield Alastair

Chief Scientific Officer

16,650 @ ——

Grant

2026-02-11

Garfield Alastair

Chief Scientific Officer

25,000 @ ——

Grant

2026-02-11

Cramer Pamela J.

Chief Human Resources Officer

11,650 @ ——

Grant

2026-02-11

Cramer Pamela J.

Chief Human Resources Officer

17,500 @ ——

Sell10b5-1

2026-02-11

Smith Hunter C

Chief Financial Officer

2,266 @ $98.37$223K

Sell10b5-1

2026-02-11

Smith Hunter C

Chief Financial Officer

400 @ $99.44$40K

Sell10b5-1

2026-02-11

Smith Hunter C

Chief Financial Officer

100 @ $100.85$10K

Grant10b5-1

2026-02-11

Smith Hunter C

Chief Financial Officer

25,000 @ ——

Grant10b5-1

2026-02-11

Smith Hunter C

Chief Financial Officer

37,500 @ ——

Sell10b5-1

2026-02-10

Smith Hunter C

Chief Financial Officer

100 @ $104.76$10K

Sell10b5-1

2026-02-10

Smith Hunter C

Chief Financial Officer

700 @ $103.68$73K

+ 41 more

Date	Insider	Action	Shares	Price	Value
2026-05-18	Smith Hunter CChief Financial Officer	Exercise	3,000	$17.87	$54K
2026-05-15	German Christopher PaulCorporate Controller & CAO	Exercise	1,406	$17.97	$25K
2026-05-15	German Christopher PaulCorporate Controller & CAO	Sell	4,643	$92.21	$428K
2026-05-15	German Christopher PaulCorporate Controller & CAO	Exercise	1,349	$49.23	$66K
2026-05-15	German Christopher PaulCorporate Controller & CAO	Exercise	1,687	$56.69	$96K
2026-04-01	Mazabraud YannEVP, Head of International	Exercise	10,375	—	—
2026-04-01	Mazabraud YannEVP, Head of International	Exercise	2,500	—	—
2026-04-01	Popovits Kimberly JDirector	Grant	6,808	—	—
2026-04-01	Popovits Kimberly JDirector	Grant	10,257	—	—
2026-04-01	Mazabraud YannEVP, Head of International	Exercise	12,875	—	—
2026-03-12	Mathers Edward TDirector	Other	4,199	—	—
2026-03-04	German Christopher PaulCorporate Controller & CAO	Exercise	1,500	$17.97	$27K
2026-03-04	German Christopher PaulCorporate Controller & CAO	Sell	5,614	$89.56	$503K
2026-03-02	Mathers Edward TDirector	Other	4,198	—	—
2026-03-02	Smith Hunter CChief Financial Officer	Exercise	6,099	$6.80	$41K
2026-03-02	Mazabraud YannEVP, Head of International	Grant	35,000	—	—
2026-03-01	German Christopher PaulCorporate Controller & CAO	Exercise	1,162	—	—
2026-03-01	German Christopher PaulCorporate Controller & CAO	Tax	342	$94.94	$32K
2026-02-19	Smith Hunter CChief Financial Officer	Sell10b5-1	800	$102.10	$82K
2026-02-19	Smith Hunter CChief Financial Officer	Sell10b5-1	1,308	$100.27	$131K
2026-02-19	Smith Hunter CChief Financial Officer	Sell10b5-1	1,692	$100.92	$171K
2026-02-19	Smith Hunter CChief Financial Officer	Sell10b5-1	585	$103.28	$60K
2026-02-17	Smith Hunter CChief Financial Officer	Sell10b5-1	900	$101.70	$92K
2026-02-17	Smith Hunter CChief Financial Officer	Sell10b5-1	1,069	$103.00	$110K
2026-02-17	Smith Hunter CChief Financial Officer	Sell10b5-1	1,200	$99.42	$119K
2026-02-17	Smith Hunter CChief Financial Officer	Sell10b5-1	200	$100.52	$20K
2026-02-14	Mazabraud YannEVP, Head of International	Exercise	10,000	—	—
2026-02-12	Smith Hunter CChief Financial Officer	Sell10b5-1	800	$98.99	$79K
2026-02-12	Smith Hunter CChief Financial Officer	Sell10b5-1	292	$96.26	$28K
2026-02-12	Smith Hunter CChief Financial Officer	Sell10b5-1	100	$100.10	$10K
2026-02-12	Smith Hunter CChief Financial Officer	Sell10b5-1	400	$97.67	$39K
2026-02-11	Lee Jennifer KaydenEVP, Head of North America	Grant	32,500	—	—
2026-02-11	Shulman JosephChief Technical Officer	Grant	15,000	—	—
2026-02-11	Shulman JosephChief Technical Officer	Grant	22,500	—	—
2026-02-11	Meeker David PPresident and CEO	Grant	71,900	—	—
2026-02-11	Meeker David PPresident and CEO	Grant	107,850	—	—
2026-02-11	Mazabraud YannEVP, Head of International	Grant	23,350	—	—
2026-02-11	Lee Jennifer KaydenEVP, Head of North America	Grant	21,650	—	—
2026-02-11	German Christopher PaulCorporate Controller & CAO	Grant	5,215	—	—
2026-02-11	Garfield AlastairChief Scientific Officer	Grant	16,650	—	—
2026-02-11	Garfield AlastairChief Scientific Officer	Grant	25,000	—	—
2026-02-11	Cramer Pamela J.Chief Human Resources Officer	Grant	11,650	—	—
2026-02-11	Cramer Pamela J.Chief Human Resources Officer	Grant	17,500	—	—
2026-02-11	Smith Hunter CChief Financial Officer	Sell10b5-1	2,266	$98.37	$223K
2026-02-11	Smith Hunter CChief Financial Officer	Sell10b5-1	400	$99.44	$40K
2026-02-11	Smith Hunter CChief Financial Officer	Sell10b5-1	100	$100.85	$10K
2026-02-11	Smith Hunter CChief Financial Officer	Grant10b5-1	25,000	—	—
2026-02-11	Smith Hunter CChief Financial Officer	Grant10b5-1	37,500	—	—
2026-02-10	Smith Hunter CChief Financial Officer	Sell10b5-1	100	$104.76	$10K
2026-02-10	Smith Hunter CChief Financial Officer	Sell10b5-1	700	$103.68	$73K

+ 41 more transactions

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