FDA approvaloutcome: successconf 1.00

dawnzera — FDA approval

$IONS · IONIS PHARMACEUTICALS INC

Event date

August 21, 2025

289 days ago

Sponsor runway

7 mo

$1.92B liquid

Evidence

“openFDA ORIG (TYPE 1) approval of DAWNZERA — application NDA219407”

Comparable historical fda approvals· last 5 years · same event type

100% hit rate (10/10)

Ticker	Drug	Date	Outcome
$INCY	zynyz	2026-05-18	success
$INCY	jakafi xr	2026-05-01	success
$AXSM	auvelity	2026-04-30	success
$INCY	zynyz	2026-03-30	success
$BIIB	spinraza	2026-03-27	success
$CORT	lifyorli	2026-03-25	success
$RYTM	imcivree	2026-03-19	success
$ASND	yuviwel	2026-02-27	success
$BMRN	palynziq	2026-02-27	success
$ETON	desmoda	2026-02-25	success

Recent insider activity· ±90 days

19 insiders · 0 buys · 79 sells

Exercise

2025-11-19

HERMAN JOAN E

Director

12,000 @ $40.05$481K

Sell

2025-11-19

HERMAN JOAN E

Director

12,000 @ $72.13$866K

Exercise

2025-11-19

HERMAN JOAN E

Director

32,000 @ $63.90$2.04M

Sell

2025-11-19

HERMAN JOAN E

Director

32,000 @ $72.13$2.31M

Exercise

2025-11-18

WENDER JOSEPH H

Director

16,000 @ $24.42$391K

Sell10b5-1

2025-11-06

Birchler Brian

EVP, Corp and Development Ops

8,000 @ $76.17$609K

Sell10b5-1

2025-11-06

Geary Richard S

EVP, Chief Development Officer

18,300 @ $75.42$1.38M

Exercise10b5-1

2025-11-06

Geary Richard S

EVP, Chief Development Officer

18,300 @ $60.89$1.11M

Sell10b5-1

2025-11-06

Geary Richard S

EVP, Chief Development Officer

14,738 @ $76.10$1.12M

Exercise10b5-1

2025-11-06

Geary Richard S

EVP, Chief Development Officer

14,738 @ $56.78$837K

Exercise10b5-1

2025-11-05

Geary Richard S

EVP, Chief Development Officer

800 @ $56.78$45K

Sell10b5-1

2025-11-05

Geary Richard S

EVP, Chief Development Officer

800 @ $75.01$60K

Sell10b5-1

2025-11-05

Geary Richard S

EVP, Chief Development Officer

801 @ $75.01$60K

Exercise10b5-1

2025-11-05

Geary Richard S

EVP, Chief Development Officer

801 @ $60.89$49K

Sell10b5-1

2025-11-03

Geary Richard S

EVP, Chief Development Officer

775 @ $75.05$58K

Exercise10b5-1

2025-11-03

Geary Richard S

EVP, Chief Development Officer

905 @ $60.89$55K

Exercise10b5-1

2025-11-03

Geary Richard S

EVP, Chief Development Officer

775 @ $56.78$44K

Sell10b5-1

2025-11-03

Geary Richard S

EVP, Chief Development Officer

905 @ $75.05$68K

Exercise10b5-1

2025-10-31

Geary Richard S

EVP, Chief Development Officer

34,664 @ $56.78$1.97M

Exercise10b5-1

2025-10-31

Geary Richard S

EVP, Chief Development Officer

34,585 @ $60.89$2.11M

Sell10b5-1

2025-10-31

Geary Richard S

EVP, Chief Development Officer

34,585 @ $75.11$2.60M

Sell10b5-1

2025-10-31

Geary Richard S

EVP, Chief Development Officer

34,664 @ $75.11$2.60M

Sell10b5-1

2025-10-31

Geary Richard S

EVP, Chief Development Officer

20,000 @ $75.11$1.50M

Exercise10b5-1

2025-10-31

LOSCALZO JOSEPH

Director

16,000 @ $52.22$836K

Sell10b5-1

2025-10-31

LOSCALZO JOSEPH

Director

16,000 @ $75.10$1.20M

Sell10b5-1

2025-10-31

WENDER JOSEPH H

Director

11,200 @ $75.16$842K

Sell10b5-1

2025-10-30

WENDER JOSEPH H

Director

8,341 @ $73.16$610K

Sell10b5-1

2025-10-30

WENDER JOSEPH H

Director

2,484 @ $72.19$179K

Sell10b5-1

2025-10-30

WENDER JOSEPH H

Director

5,975 @ $73.85$441K

Sell10b5-1

2025-10-16

Devers Shannon L.

EVP, Chief Human Resources Ofc

1,263 @ $73.62$93K

Sell

2025-10-16

Swayze Eric

EVP Research

53 @ $73.62$4K

Exercise

2025-10-15

Swayze Eric

EVP Research

125 @ ——

Sell10b5-1

2025-10-15

PARSHALL B LYNNE

Director

5,000 @ $71.74$359K

Exercise10b5-1

2025-10-15

Devers Shannon L.

EVP, Chief Human Resources Ofc

6,000 @ $48.51$291K

Sell10b5-1

2025-10-15

Devers Shannon L.

EVP, Chief Human Resources Ofc

6,000 @ $72.94$438K

Exercise10b5-1

2025-10-15

Devers Shannon L.

EVP, Chief Human Resources Ofc

2,820 @ ——

Sell10b5-1

2025-10-15

Birchler Brian

EVP, Corp and Development Ops

12,425 @ $72.23$897K

Exercise10b5-1

2025-10-15

Birchler Brian

EVP, Corp and Development Ops

12,425 @ $53.77$668K

Exercise10b5-1

2025-10-14

Birchler Brian

EVP, Corp and Development Ops

11,475 @ $53.77$617K

Sell10b5-1

2025-10-14

Birchler Brian

EVP, Corp and Development Ops

11,475 @ $72.03$827K

Sell10b5-1

2025-10-06

Swayze Eric

EVP Research

6,849 @ $69.02$473K

Exercise10b5-1

2025-10-06

O'NEIL PATRICK R.

EVP CLO & General Counsel

10,200 @ $52.87$539K

Sell10b5-1

2025-10-06

O'NEIL PATRICK R.

EVP CLO & General Counsel

10,200 @ $69.89$713K

Sell10b5-1

2025-10-06

O'NEIL PATRICK R.

EVP CLO & General Counsel

3,241 @ $69.27$224K

Sell10b5-1

2025-10-06

Baroldi Joseph

EVP, Chief Business Officer

1,625 @ $69.37$113K

Sell10b5-1

2025-10-06

Monia Brett P

Chief Executive Officer

437 @ $69.26$30K

Sell10b5-1

2025-10-02

Swayze Eric

EVP Research

12,972 @ $66.23$859K

Exercise10b5-1

2025-10-02

Swayze Eric

EVP Research

12,972 @ $53.77$698K

Exercise10b5-1

2025-10-02

O'NEIL PATRICK R.

EVP CLO & General Counsel

30,203 @ $56.78$1.71M

Sell10b5-1

2025-10-02

O'NEIL PATRICK R.

EVP CLO & General Counsel

30,203 @ $67.69$2.04M

+ 114 more

Date	Insider	Action	Shares	Price	Value
2025-11-19	HERMAN JOAN EDirector	Exercise	12,000	$40.05	$481K
2025-11-19	HERMAN JOAN EDirector	Sell	12,000	$72.13	$866K
2025-11-19	HERMAN JOAN EDirector	Exercise	32,000	$63.90	$2.04M
2025-11-19	HERMAN JOAN EDirector	Sell	32,000	$72.13	$2.31M
2025-11-18	WENDER JOSEPH HDirector	Exercise	16,000	$24.42	$391K
2025-11-06	Birchler BrianEVP, Corp and Development Ops	Sell10b5-1	8,000	$76.17	$609K
2025-11-06	Geary Richard SEVP, Chief Development Officer	Sell10b5-1	18,300	$75.42	$1.38M
2025-11-06	Geary Richard SEVP, Chief Development Officer	Exercise10b5-1	18,300	$60.89	$1.11M
2025-11-06	Geary Richard SEVP, Chief Development Officer	Sell10b5-1	14,738	$76.10	$1.12M
2025-11-06	Geary Richard SEVP, Chief Development Officer	Exercise10b5-1	14,738	$56.78	$837K
2025-11-05	Geary Richard SEVP, Chief Development Officer	Exercise10b5-1	800	$56.78	$45K
2025-11-05	Geary Richard SEVP, Chief Development Officer	Sell10b5-1	800	$75.01	$60K
2025-11-05	Geary Richard SEVP, Chief Development Officer	Sell10b5-1	801	$75.01	$60K
2025-11-05	Geary Richard SEVP, Chief Development Officer	Exercise10b5-1	801	$60.89	$49K
2025-11-03	Geary Richard SEVP, Chief Development Officer	Sell10b5-1	775	$75.05	$58K
2025-11-03	Geary Richard SEVP, Chief Development Officer	Exercise10b5-1	905	$60.89	$55K
2025-11-03	Geary Richard SEVP, Chief Development Officer	Exercise10b5-1	775	$56.78	$44K
2025-11-03	Geary Richard SEVP, Chief Development Officer	Sell10b5-1	905	$75.05	$68K
2025-10-31	Geary Richard SEVP, Chief Development Officer	Exercise10b5-1	34,664	$56.78	$1.97M
2025-10-31	Geary Richard SEVP, Chief Development Officer	Exercise10b5-1	34,585	$60.89	$2.11M
2025-10-31	Geary Richard SEVP, Chief Development Officer	Sell10b5-1	34,585	$75.11	$2.60M
2025-10-31	Geary Richard SEVP, Chief Development Officer	Sell10b5-1	34,664	$75.11	$2.60M
2025-10-31	Geary Richard SEVP, Chief Development Officer	Sell10b5-1	20,000	$75.11	$1.50M
2025-10-31	LOSCALZO JOSEPHDirector	Exercise10b5-1	16,000	$52.22	$836K
2025-10-31	LOSCALZO JOSEPHDirector	Sell10b5-1	16,000	$75.10	$1.20M
2025-10-31	WENDER JOSEPH HDirector	Sell10b5-1	11,200	$75.16	$842K
2025-10-30	WENDER JOSEPH HDirector	Sell10b5-1	8,341	$73.16	$610K
2025-10-30	WENDER JOSEPH HDirector	Sell10b5-1	2,484	$72.19	$179K
2025-10-30	WENDER JOSEPH HDirector	Sell10b5-1	5,975	$73.85	$441K
2025-10-16	Devers Shannon L.EVP, Chief Human Resources Ofc	Sell10b5-1	1,263	$73.62	$93K
2025-10-16	Swayze EricEVP Research	Sell	53	$73.62	$4K
2025-10-15	Swayze EricEVP Research	Exercise	125	—	—
2025-10-15	PARSHALL B LYNNEDirector	Sell10b5-1	5,000	$71.74	$359K
2025-10-15	Devers Shannon L.EVP, Chief Human Resources Ofc	Exercise10b5-1	6,000	$48.51	$291K
2025-10-15	Devers Shannon L.EVP, Chief Human Resources Ofc	Sell10b5-1	6,000	$72.94	$438K
2025-10-15	Devers Shannon L.EVP, Chief Human Resources Ofc	Exercise10b5-1	2,820	—	—
2025-10-15	Birchler BrianEVP, Corp and Development Ops	Sell10b5-1	12,425	$72.23	$897K
2025-10-15	Birchler BrianEVP, Corp and Development Ops	Exercise10b5-1	12,425	$53.77	$668K
2025-10-14	Birchler BrianEVP, Corp and Development Ops	Exercise10b5-1	11,475	$53.77	$617K
2025-10-14	Birchler BrianEVP, Corp and Development Ops	Sell10b5-1	11,475	$72.03	$827K
2025-10-06	Swayze EricEVP Research	Sell10b5-1	6,849	$69.02	$473K
2025-10-06	O'NEIL PATRICK R.EVP CLO & General Counsel	Exercise10b5-1	10,200	$52.87	$539K
2025-10-06	O'NEIL PATRICK R.EVP CLO & General Counsel	Sell10b5-1	10,200	$69.89	$713K
2025-10-06	O'NEIL PATRICK R.EVP CLO & General Counsel	Sell10b5-1	3,241	$69.27	$224K
2025-10-06	Baroldi JosephEVP, Chief Business Officer	Sell10b5-1	1,625	$69.37	$113K
2025-10-06	Monia Brett PChief Executive Officer	Sell10b5-1	437	$69.26	$30K
2025-10-02	Swayze EricEVP Research	Sell10b5-1	12,972	$66.23	$859K
2025-10-02	Swayze EricEVP Research	Exercise10b5-1	12,972	$53.77	$698K
2025-10-02	O'NEIL PATRICK R.EVP CLO & General Counsel	Exercise10b5-1	30,203	$56.78	$1.71M
2025-10-02	O'NEIL PATRICK R.EVP CLO & General Counsel	Sell10b5-1	30,203	$67.69	$2.04M

+ 114 more transactions

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