FDA approvaloutcome: successconf 1.00

imcivree — FDA approval

$RYTM · RHYTHM PHARMACEUTICALS, INC.

Event date

December 20, 2024

533 days ago

Sponsor runway

23 mo

$340.6M liquid

Evidence

“openFDA SUPPL (EFFICACY) approval of IMCIVREE — application NDA213793”

Source ↗

Comparable historical fda approvals· last 5 years · same event type

100% hit rate (10/10)

Ticker	Drug	Date	Outcome
$INCY	zynyz	2026-05-18	success
$INCY	jakafi xr	2026-05-01	success
$AXSM	auvelity	2026-04-30	success
$INCY	zynyz	2026-03-30	success
$BIIB	spinraza	2026-03-27	success
$CORT	lifyorli	2026-03-25	success
$RYTM	imcivree	2026-03-19	success
$ASND	yuviwel	2026-02-27	success
$BMRN	palynziq	2026-02-27	success
$ETON	desmoda	2026-02-25	success

Recent insider activity· ±90 days

8 insiders · 0 buys · 43 sells

Exercise

2025-03-20

German Christopher Paul

Corporate Controller & CAO

1,163 @ ——

Exercise10b5-1

2025-03-14

Mazabraud Yann

EVP, Head of International

75,000 @ $22.28$1.67M

Sell10b5-1

2025-03-14

Mazabraud Yann

EVP, Head of International

19,197 @ $50.79$975K

Sell10b5-1

2025-03-14

Mazabraud Yann

EVP, Head of International

55,803 @ $51.72$2.89M

Sell10b5-1

2025-02-19

Smith Hunter C

Chief Financial Officer

2,215 @ $57.22$127K

Sell10b5-1

2025-02-19

Cramer Pamela J.

Chief Human Resources Officer

982 @ $57.22$56K

Sell

2025-02-19

German Christopher Paul

Corporate Controller & CAO

635 @ $57.22$36K

Sell10b5-1

2025-02-19

Shulman Joseph

Chief Technical Officer

1,228 @ $57.22$70K

Sell10b5-1

2025-02-19

Lee Jennifer Kayden

EVP, Head of North America

2,035 @ $57.22$116K

Sell10b5-1

2025-02-19

Meeker David P

President and CEO

9,896 @ $57.22$566K

Exercise10b5-1

2025-02-16

Lee Jennifer Kayden

EVP, Head of North America

5,500 @ ——

Exercise10b5-1

2025-02-16

Meeker David P

President and CEO

21,250 @ ——

Exercise

2025-02-16

German Christopher Paul

Corporate Controller & CAO

1,807 @ ——

Exercise10b5-1

2025-02-16

Shulman Joseph

Chief Technical Officer

4,125 @ ——

Exercise10b5-1

2025-02-16

Smith Hunter C

Chief Financial Officer

6,600 @ ——

Exercise

2025-02-16

Mazabraud Yann

EVP, Head of International

5,500 @ ——

Exercise10b5-1

2025-02-16

Cramer Pamela J.

Chief Human Resources Officer

3,300 @ ——

Grant10b5-1

2025-02-14

Smith Hunter C

Chief Financial Officer

62,500 @ ——

Grant

2025-02-14

Mazabraud Yann

EVP, Head of International

40,000 @ ——

Grant10b5-1

2025-02-14

Cramer Pamela J.

Chief Human Resources Officer

30,000 @ ——

Grant

2025-02-14

Mazabraud Yann

EVP, Head of International

60,000 @ ——

Grant

2025-02-14

German Christopher Paul

Corporate Controller & CAO

7,225 @ ——

Grant

2025-02-14

German Christopher Paul

Corporate Controller & CAO

5,400 @ ——

Grant

2025-02-14

Garfield Alastair

Chief Scientific Officer

40,000 @ ——

Grant

2025-02-14

Garfield Alastair

Chief Scientific Officer

26,650 @ ——

Grant10b5-1

2025-02-14

Smith Hunter C

Chief Financial Officer

41,650 @ ——

Grant10b5-1

2025-02-14

Cramer Pamela J.

Chief Human Resources Officer

20,000 @ ——

Grant10b5-1

2025-02-14

Lee Jennifer Kayden

EVP, Head of North America

55,000 @ ——

Grant10b5-1

2025-02-14

Lee Jennifer Kayden

EVP, Head of North America

36,650 @ ——

Grant10b5-1

2025-02-14

Meeker David P

President and CEO

133,350 @ ——

Grant10b5-1

2025-02-14

Meeker David P

President and CEO

200,000 @ ——

Grant10b5-1

2025-02-14

Shulman Joseph

Chief Technical Officer

25,000 @ ——

Grant10b5-1

2025-02-14

Shulman Joseph

Chief Technical Officer

37,500 @ ——

Sell10b5-1

2025-02-13

Lee Jennifer Kayden

EVP, Head of North America

1,205 @ $58.00$70K

Sell10b5-1

2025-02-12

Lee Jennifer Kayden

EVP, Head of North America

1,205 @ $56.39$68K

Sell10b5-1

2025-02-12

Smith Hunter C

Chief Financial Officer

739 @ $56.39$42K

Sell10b5-1

2025-02-12

Smith Hunter C

Chief Financial Officer

12 @ $56.22$675

Sell10b5-1

2025-02-12

Shulman Joseph

Chief Technical Officer

462 @ $56.39$26K

Sell10b5-1

2025-02-12

Shulman Joseph

Chief Technical Officer

7 @ $57.09$400

Sell10b5-1

2025-02-12

Lee Jennifer Kayden

EVP, Head of North America

600 @ $56.39$34K

Sell10b5-1

2025-02-12

Lee Jennifer Kayden

EVP, Head of North America

10 @ $56.41$564

Sell10b5-1

2025-02-11

Smith Hunter C

Chief Financial Officer

1,291 @ $57.51$74K

Sell10b5-1

2025-02-11

Shulman Joseph

Chief Technical Officer

791 @ $57.51$45K

Exercise10b5-1

2025-02-11

Lee Jennifer Kayden

EVP, Head of North America

2,031 @ ——

Sell10b5-1

2025-02-11

Lee Jennifer Kayden

EVP, Head of North America

1,023 @ $57.51$59K

Exercise10b5-1

2025-02-11

Shulman Joseph

Chief Technical Officer

1,562 @ ——

Exercise10b5-1

2025-02-11

Smith Hunter C

Chief Financial Officer

2,343 @ ——

Sell10b5-1

2025-02-11

Smith Hunter C

Chief Financial Officer

5 @ $57.53$288

Sell10b5-1

2025-02-11

Cramer Pamela J.

Chief Human Resources Officer

3 @ $57.54$173

Sell10b5-1

2025-02-11

Cramer Pamela J.

Chief Human Resources Officer

698 @ $57.51$40K

+ 38 more

Date	Insider	Action	Shares	Price	Value
2025-03-20	German Christopher PaulCorporate Controller & CAO	Exercise	1,163	—	—
2025-03-14	Mazabraud YannEVP, Head of International	Exercise10b5-1	75,000	$22.28	$1.67M
2025-03-14	Mazabraud YannEVP, Head of International	Sell10b5-1	19,197	$50.79	$975K
2025-03-14	Mazabraud YannEVP, Head of International	Sell10b5-1	55,803	$51.72	$2.89M
2025-02-19	Smith Hunter CChief Financial Officer	Sell10b5-1	2,215	$57.22	$127K
2025-02-19	Cramer Pamela J.Chief Human Resources Officer	Sell10b5-1	982	$57.22	$56K
2025-02-19	German Christopher PaulCorporate Controller & CAO	Sell	635	$57.22	$36K
2025-02-19	Shulman JosephChief Technical Officer	Sell10b5-1	1,228	$57.22	$70K
2025-02-19	Lee Jennifer KaydenEVP, Head of North America	Sell10b5-1	2,035	$57.22	$116K
2025-02-19	Meeker David PPresident and CEO	Sell10b5-1	9,896	$57.22	$566K
2025-02-16	Lee Jennifer KaydenEVP, Head of North America	Exercise10b5-1	5,500	—	—
2025-02-16	Meeker David PPresident and CEO	Exercise10b5-1	21,250	—	—
2025-02-16	German Christopher PaulCorporate Controller & CAO	Exercise	1,807	—	—
2025-02-16	Shulman JosephChief Technical Officer	Exercise10b5-1	4,125	—	—
2025-02-16	Smith Hunter CChief Financial Officer	Exercise10b5-1	6,600	—	—
2025-02-16	Mazabraud YannEVP, Head of International	Exercise	5,500	—	—
2025-02-16	Cramer Pamela J.Chief Human Resources Officer	Exercise10b5-1	3,300	—	—
2025-02-14	Smith Hunter CChief Financial Officer	Grant10b5-1	62,500	—	—
2025-02-14	Mazabraud YannEVP, Head of International	Grant	40,000	—	—
2025-02-14	Cramer Pamela J.Chief Human Resources Officer	Grant10b5-1	30,000	—	—
2025-02-14	Mazabraud YannEVP, Head of International	Grant	60,000	—	—
2025-02-14	German Christopher PaulCorporate Controller & CAO	Grant	7,225	—	—
2025-02-14	German Christopher PaulCorporate Controller & CAO	Grant	5,400	—	—
2025-02-14	Garfield AlastairChief Scientific Officer	Grant	40,000	—	—
2025-02-14	Garfield AlastairChief Scientific Officer	Grant	26,650	—	—
2025-02-14	Smith Hunter CChief Financial Officer	Grant10b5-1	41,650	—	—
2025-02-14	Cramer Pamela J.Chief Human Resources Officer	Grant10b5-1	20,000	—	—
2025-02-14	Lee Jennifer KaydenEVP, Head of North America	Grant10b5-1	55,000	—	—
2025-02-14	Lee Jennifer KaydenEVP, Head of North America	Grant10b5-1	36,650	—	—
2025-02-14	Meeker David PPresident and CEO	Grant10b5-1	133,350	—	—
2025-02-14	Meeker David PPresident and CEO	Grant10b5-1	200,000	—	—
2025-02-14	Shulman JosephChief Technical Officer	Grant10b5-1	25,000	—	—
2025-02-14	Shulman JosephChief Technical Officer	Grant10b5-1	37,500	—	—
2025-02-13	Lee Jennifer KaydenEVP, Head of North America	Sell10b5-1	1,205	$58.00	$70K
2025-02-12	Lee Jennifer KaydenEVP, Head of North America	Sell10b5-1	1,205	$56.39	$68K
2025-02-12	Smith Hunter CChief Financial Officer	Sell10b5-1	739	$56.39	$42K
2025-02-12	Smith Hunter CChief Financial Officer	Sell10b5-1	12	$56.22	$675
2025-02-12	Shulman JosephChief Technical Officer	Sell10b5-1	462	$56.39	$26K
2025-02-12	Shulman JosephChief Technical Officer	Sell10b5-1	7	$57.09	$400
2025-02-12	Lee Jennifer KaydenEVP, Head of North America	Sell10b5-1	600	$56.39	$34K
2025-02-12	Lee Jennifer KaydenEVP, Head of North America	Sell10b5-1	10	$56.41	$564
2025-02-11	Smith Hunter CChief Financial Officer	Sell10b5-1	1,291	$57.51	$74K
2025-02-11	Shulman JosephChief Technical Officer	Sell10b5-1	791	$57.51	$45K
2025-02-11	Lee Jennifer KaydenEVP, Head of North America	Exercise10b5-1	2,031	—	—
2025-02-11	Lee Jennifer KaydenEVP, Head of North America	Sell10b5-1	1,023	$57.51	$59K
2025-02-11	Shulman JosephChief Technical Officer	Exercise10b5-1	1,562	—	—
2025-02-11	Smith Hunter CChief Financial Officer	Exercise10b5-1	2,343	—	—
2025-02-11	Smith Hunter CChief Financial Officer	Sell10b5-1	5	$57.53	$288
2025-02-11	Cramer Pamela J.Chief Human Resources Officer	Sell10b5-1	3	$57.54	$173
2025-02-11	Cramer Pamela J.Chief Human Resources Officer	Sell10b5-1	698	$57.51	$40K

+ 38 more transactions

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