FDA approvaloutcome: successconf 1.00

onpattro — FDA approval

$ALNY · ALNYLAM PHARMACEUTICALS, INC.

Event date

January 13, 2023

1240 days ago

Sponsor runway

cash-flow +

$1.66B liquid

Evidence

“openFDA SUPPL (EFFICACY) approval of ONPATTRO — application NDA210922”

Source ↗

Comparable historical fda approvals· last 5 years · same event type

100% hit rate (10/10)

Ticker	Drug	Date	Outcome
$INCY	zynyz	2026-05-18	success
$INCY	jakafi xr	2026-05-01	success
$AXSM	auvelity	2026-04-30	success
$INCY	zynyz	2026-03-30	success
$BIIB	spinraza	2026-03-27	success
$CORT	lifyorli	2026-03-25	success
$RYTM	imcivree	2026-03-19	success
$ASND	yuviwel	2026-02-27	success
$BMRN	palynziq	2026-02-27	success
$ETON	desmoda	2026-02-25	success

Recent insider activity· ±90 days

13 insiders · 0 buys · 21 sells

Sell

2023-04-06

Franchini Indrani Lall

EVP, CLO & Secretary

3,500 @ $210.00$735K

Grant

2023-03-07

KELLOGG PETER N

Director

4,948 @ ——

Exercise

2023-03-03

Garg Pushkal

EVP Chief R&D

2,500 @ $96.45$241K

Sell

2023-03-03

Garg Pushkal

EVP Chief R&D

18,072 @ $200.00$3.61M

Grant

2023-02-27

Vaishnaw Akshay

President

11,986 @ ——

Grant

2023-02-27

Greenstreet Yvonne

Chief Executive Officer

36,775 @ ——

Grant

2023-02-27

Tanguler Tolga

EVP, Chief Commercial Officer

5,000 @ ——

Grant

2023-02-27

Tanguler Tolga

EVP, Chief Commercial Officer

10,352 @ ——

Grant

2023-02-27

Vaishnaw Akshay

President

5,790 @ ——

Grant

2023-02-27

Franchini Indrani Lall

EVP, CLO & Secretary

2,632 @ ——

Grant

2023-02-27

Poulton Jeffrey V.

EVP, Chief Financial Officer

5,724 @ ——

Grant

2023-02-27

Franchini Indrani Lall

EVP, CLO & Secretary

5,449 @ ——

Grant

2023-02-27

Poulton Jeffrey V.

EVP, Chief Financial Officer

11,850 @ ——

Grant

2023-02-27

Garg Pushkal

EVP Chief R&D

11,850 @ ——

Grant

2023-02-27

Garg Pushkal

EVP Chief R&D

5,724 @ ——

Grant

2023-02-27

Greenstreet Yvonne

Chief Executive Officer

17,763 @ ——

Exercise

2023-02-23

SCHULMAN AMY W

Director

136 @ ——

Exercise

2023-02-23

PYOTT DAVID E I

Director

136 @ ——

Exercise

2023-02-23

Fanucci Marsha

Director

136 @ ——

Exercise

2023-02-23

Ausiello Dennis A

Director

136 @ ——

Exercise

2023-02-23

HAMBURG MARGARET A

Director

136 @ ——

Sell

2023-02-10

Vaishnaw Akshay

President

4,302 @ $217.05$934K

Exercise

2023-02-10

Vaishnaw Akshay

President

30,913 @ $63.00$1.95M

Sell

2023-02-10

Vaishnaw Akshay

President

1,709 @ $213.13$364K

Sell

2023-02-10

Vaishnaw Akshay

President

2,307 @ $214.28$494K

Sell

2023-02-10

Vaishnaw Akshay

President

10,279 @ $215.59$2.22M

Sell

2023-02-10

Vaishnaw Akshay

President

19,447 @ $216.38$4.21M

Sell

2023-02-03

Tanguler Tolga

EVP, Chief Commercial Officer

128 @ $227.68$29K

Sell

2023-02-03

Tanguler Tolga

EVP, Chief Commercial Officer

1,293 @ $232.53$301K

Sell

2023-02-03

Tanguler Tolga

EVP, Chief Commercial Officer

865 @ $231.35$200K

Sell

2023-02-03

Tanguler Tolga

EVP, Chief Commercial Officer

185 @ $230.20$43K

Sell

2023-02-03

Tanguler Tolga

EVP, Chief Commercial Officer

953 @ $233.31$222K

Sell

2023-02-02

Franchini Indrani Lall

EVP, CLO & Secretary

1,007 @ $225.80$227K

Sell

2023-02-02

Tanguler Tolga

EVP, Chief Commercial Officer

73 @ $223.97$16K

Sell

2023-02-02

Tanguler Tolga

EVP, Chief Commercial Officer

963 @ $225.80$217K

Sell

2023-02-02

Tanguler Tolga

EVP, Chief Commercial Officer

561 @ $226.62$127K

Sell

2023-02-02

Tanguler Tolga

EVP, Chief Commercial Officer

4 @ $227.38$910

Sell

2023-02-02

Franchini Indrani Lall

EVP, CLO & Secretary

77 @ $223.97$17K

Sell

2023-02-02

Franchini Indrani Lall

EVP, CLO & Secretary

586 @ $226.62$133K

Sell

2023-02-02

Franchini Indrani Lall

EVP, CLO & Secretary

5 @ $227.38$1K

Exercise

2023-02-01

Franchini Indrani Lall

EVP, CLO & Secretary

5,175 @ ——

Exercise

2023-02-01

Tanguler Tolga

EVP, Chief Commercial Officer

5,025 @ ——

Grant

2023-01-05

Bertozzi Carolyn R

Director

4,268 @ ——

Exercise

2022-12-05

Vaishnaw Akshay

President

2,368 @ $42.22$100K

Exercise

2022-12-05

Vaishnaw Akshay

President

1,587 @ $63.00$100K

Exercise

2022-12-05

Vaishnaw Akshay

President

1,124 @ $88.95$100K

Tax

2022-12-05

Vaishnaw Akshay

President

1,324 @ $226.20$299K

Exercise

2022-11-21

Ausiello Dennis A

Director

11,250 @ $70.20$790K

Sell

2022-11-21

Ausiello Dennis A

Director

22,500 @ $220.00$4.95M

Date	Insider	Action	Shares	Price	Value
2023-04-06	Franchini Indrani LallEVP, CLO & Secretary	Sell	3,500	$210.00	$735K
2023-03-07	KELLOGG PETER NDirector	Grant	4,948	—	—
2023-03-03	Garg PushkalEVP Chief R&D	Exercise	2,500	$96.45	$241K
2023-03-03	Garg PushkalEVP Chief R&D	Sell	18,072	$200.00	$3.61M
2023-02-27	Vaishnaw AkshayPresident	Grant	11,986	—	—
2023-02-27	Greenstreet YvonneChief Executive Officer	Grant	36,775	—	—
2023-02-27	Tanguler TolgaEVP, Chief Commercial Officer	Grant	5,000	—	—
2023-02-27	Tanguler TolgaEVP, Chief Commercial Officer	Grant	10,352	—	—
2023-02-27	Vaishnaw AkshayPresident	Grant	5,790	—	—
2023-02-27	Franchini Indrani LallEVP, CLO & Secretary	Grant	2,632	—	—
2023-02-27	Poulton Jeffrey V.EVP, Chief Financial Officer	Grant	5,724	—	—
2023-02-27	Franchini Indrani LallEVP, CLO & Secretary	Grant	5,449	—	—
2023-02-27	Poulton Jeffrey V.EVP, Chief Financial Officer	Grant	11,850	—	—
2023-02-27	Garg PushkalEVP Chief R&D	Grant	11,850	—	—
2023-02-27	Garg PushkalEVP Chief R&D	Grant	5,724	—	—
2023-02-27	Greenstreet YvonneChief Executive Officer	Grant	17,763	—	—
2023-02-23	SCHULMAN AMY WDirector	Exercise	136	—	—
2023-02-23	PYOTT DAVID E IDirector	Exercise	136	—	—
2023-02-23	Fanucci MarshaDirector	Exercise	136	—	—
2023-02-23	Ausiello Dennis ADirector	Exercise	136	—	—
2023-02-23	HAMBURG MARGARET ADirector	Exercise	136	—	—
2023-02-10	Vaishnaw AkshayPresident	Sell	4,302	$217.05	$934K
2023-02-10	Vaishnaw AkshayPresident	Exercise	30,913	$63.00	$1.95M
2023-02-10	Vaishnaw AkshayPresident	Sell	1,709	$213.13	$364K
2023-02-10	Vaishnaw AkshayPresident	Sell	2,307	$214.28	$494K
2023-02-10	Vaishnaw AkshayPresident	Sell	10,279	$215.59	$2.22M
2023-02-10	Vaishnaw AkshayPresident	Sell	19,447	$216.38	$4.21M
2023-02-03	Tanguler TolgaEVP, Chief Commercial Officer	Sell	128	$227.68	$29K
2023-02-03	Tanguler TolgaEVP, Chief Commercial Officer	Sell	1,293	$232.53	$301K
2023-02-03	Tanguler TolgaEVP, Chief Commercial Officer	Sell	865	$231.35	$200K
2023-02-03	Tanguler TolgaEVP, Chief Commercial Officer	Sell	185	$230.20	$43K
2023-02-03	Tanguler TolgaEVP, Chief Commercial Officer	Sell	953	$233.31	$222K
2023-02-02	Franchini Indrani LallEVP, CLO & Secretary	Sell	1,007	$225.80	$227K
2023-02-02	Tanguler TolgaEVP, Chief Commercial Officer	Sell	73	$223.97	$16K
2023-02-02	Tanguler TolgaEVP, Chief Commercial Officer	Sell	963	$225.80	$217K
2023-02-02	Tanguler TolgaEVP, Chief Commercial Officer	Sell	561	$226.62	$127K
2023-02-02	Tanguler TolgaEVP, Chief Commercial Officer	Sell	4	$227.38	$910
2023-02-02	Franchini Indrani LallEVP, CLO & Secretary	Sell	77	$223.97	$17K
2023-02-02	Franchini Indrani LallEVP, CLO & Secretary	Sell	586	$226.62	$133K
2023-02-02	Franchini Indrani LallEVP, CLO & Secretary	Sell	5	$227.38	$1K
2023-02-01	Franchini Indrani LallEVP, CLO & Secretary	Exercise	5,175	—	—
2023-02-01	Tanguler TolgaEVP, Chief Commercial Officer	Exercise	5,025	—	—
2023-01-05	Bertozzi Carolyn RDirector	Grant	4,268	—	—
2022-12-05	Vaishnaw AkshayPresident	Exercise	2,368	$42.22	$100K
2022-12-05	Vaishnaw AkshayPresident	Exercise	1,587	$63.00	$100K
2022-12-05	Vaishnaw AkshayPresident	Exercise	1,124	$88.95	$100K
2022-12-05	Vaishnaw AkshayPresident	Tax	1,324	$226.20	$299K
2022-11-21	Ausiello Dennis ADirector	Exercise	11,250	$70.20	$790K
2022-11-21	Ausiello Dennis ADirector	Sell	22,500	$220.00	$4.95M

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